CYP2C9*3 allelic variant is associated with metabolism of irbesartan in Chinese population
详细信息 查看全文
- 作者：Xiumei Hong ; Shanchun Zhang ; Guangyun Mao ; Shanqun Jiang ; Yan Zhang ; Yunxian Yu ; Genfu Tang ; Houxun Xing and Xiping Xu
- 关键词：CYP2C9*3 allele ; Irbesartan ; Pharmacokinetics
- 刊名：European Journal of Clinical Pharmacology
- 出版年：2005
- 出版时间：October 2005
- 年：2005
- 卷：61
- 期：9
- 页码：627-634
- 全文大小：242 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1041
文摘
Objective There is considerable variability in the individual pharmaceutical dosages required to achieve optimal therapeutic effects, which may be due to environmental or genetic factors. The objective of this study was to test the presence of the CYP2C9*3 allelic variant in the Chinese population and to investigate the association of this variant with both metabolism and therapeutic efficacy of irbesartan on essential hypertension.