Characterization and release kinetics of liposomes inserted by pH-responsive bola-polymer

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• 作者：Weiju Hao ; Tian Xia ; Yazhuo Shang ; Shouhong Xu ; Honglai Liu
• 刊名：Colloid & Polymer Science
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：294
• 期：7
• 页码：1107-1116
• 全文大小：1,875 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536
• 卷排序：294

文摘

One important thing in tumor chemotherapy is to develop the targeting, precise timing, and quantitative drug delivery/release system. According to the weak acid of tumor extracellular environment, a pH-sensitive bola-type triblock copolymer (PEG_m-PDPA_n-PEG_m) was synthesized and mixed with phospholipid to form functional hybrid liposomes (liposome@Bola). When compared to pure liposome, the stability of the liposome@Bola was enhanced greatly and the drug leakage was inhibited at pH 7.4. However, under pH 6.0, the drug released quickly through the nanopores on the lipid bilayer created by the escape of copolymers. Under a strongly acidic environment, the drug release of liposome@Bola could be blocked again due to the coverage of free copolymers. The kinetic curves of drug release had been modeled by using some frequently used models. It was found that the release of liposome@Bola under pH 6.0 was biphasic with a slow release by means of membrane permeation and a rapid second phase which was released through nanopores on liposome membrane. The results indicated that the pH-responsive liposome@Bola could be expected to be a good potential in controllable drug delivery system.KeywordsLiposomeBola-polymerpH responsibilityControlled releaseSmart drug delivery