The Changes of Pro-opiomelanocortin Neurons in Type 2 Diabetes Mellitus Rats After Ileal Transposition: The Role of POMC Neurons

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• 作者：Weijie Chen (1)
  Zhibo Yan (1)
  Shaozhuang Liu (1)
  Guangyong Zhang (1)
  Dong Sun (1)
  Sanyuan Hu (1)
  
• 关键词：POMC ; Type 2 diabetes mellitus ; Glucagon ; like peptide ; 1
• 刊名：Journal of Gastrointestinal Surgery
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：15
• 期：9
• 页码：1618-1624
• 全文大小：247KB
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• 作者单位：Weijie Chen (1)
  Zhibo Yan (1)
  Shaozhuang Liu (1)
  Guangyong Zhang (1)
  Dong Sun (1)
  Sanyuan Hu (1)
  
  1. Department of General Surgery, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China
  

文摘

Background Ileal transposition (IT) can effectively resolve obesity and improve type 2 diabetes. IT is associated with increased glucagon-like peptide 1 secretion. The mechanisms mediating the effects of IT on obesity and diabetes remain undefined. Given the role of pro-opiomelanocortin neurons in energy balance, we sought to determine its potential role in these processes. Methods Twenty non-obese diabetic Goto–Kakizaki rats underwent either IT or sham operation. Various measures including food intake, body weight, fasting plasma glucose, glucagon-like peptide 1 level, activated pro-opiomelanocortin neuron number, and pro-opiomelanocortin mRNA expression were evaluated. Results The IT group demonstrated significantly improved plasma glucose homeostasis with increased glucagon-like peptide 1 secretion. The IT group ate less and demonstrated reduced body weight gain over time. These effects were also associated with increased central neuronal activity with increased pro-opiomelanocortin and derivative gene expression in the hypothalamus and increased protein expression in the pituitary gland. Conclusions More pro-opiomelanocortin neurons in the hypothalamus of diabetes rats were activated after ileal transposition. These data suggest a potential important role for pro-opiomelanocortin neurons in the resolution of diabetes after IT.