Myocardial Insulin Signaling and Glucose Transport Are Up-regulated in Goto–Kakizaki Type 2 Diabetic Rats After Ileal Transposition

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• 作者：Zhibo Yan (1)
  Weijie Chen (1)
  Shaozhuang Liu (1)
  Guangyong Zhang (1)
  Dong Sun (1)
  Sanyuan Hu (1)
  
• 关键词：Ileal transposition ; Type 2 diabetes mellitus ; Myocardial insulin signaling
• 刊名：Obesity Surgery
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：22
• 期：3
• 页码：493-501
• 全文大小：410KB
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• 作者单位：Zhibo Yan (1)
  Weijie Chen (1)
  Shaozhuang Liu (1)
  Guangyong Zhang (1)
  Dong Sun (1)
  Sanyuan Hu (1)
  
  1. Department of General Surgery, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China
  

文摘

Background Ileal transposition (IT) as one of the effective treatments for non-obese type 2 diabetes mellitus has been widely investigated. However, the mechanisms underlying profound improvements in glucose homeostasis are still uncertain. Our objective was to explore the myocardial insulin signal transduction and glucose disposal in non-obese type 2 diabetes mellitus rats after IT surgery. Methods Adult male Goto–Kakizaki (GK) rats or Sprague–Dawley (SD) rats were randomly assigned to diabetic IT, diabetic sham-IT, and non-diabetic control SD groups. Food intake, body weight, fasting plasma glucose, insulin tolerance, and serum glucagon-like peptide-1 (GLP-1) were measured. Subsequently, the myocardial glucose uptake and the protein levels of insulin receptor-beta (IR-β), phosphorylated IR-β, insulin receptor substrate 1 (IRS-1), phosphorylated IRS-1, and IRS-1-associated phosphatidylinositol-3 kinase (PI3K) from myocardial cell lysates were evaluated. We also assessed the expression of glucose transporter 4 (GLUT4) in both skeletal muscle and myocardial cell lysates. Results Compared to sham operations within 6?months, IT surgery for GK rats did (1) result in less food intake and reduced body weight gain over time, (2) improve plasma glucose homeostasis with increased serum GLP-1 secretion and myocardial glucose uptake, (3) increase protein expression of insulin signaling pathway, including IR-β, IRS-1 and their phosphorylation levels, and IRS-1-associated PI3K in the myocardium, and (4) enhance the protein levels of membrane GLUT4 in skeletal muscle and myocardium. Conclusions IT surgery ameliorates glucose disorder in GK type 2 diabetic rats. Meanwhile, IT surgery is effective in up-regulating both myocardial insulin signaling and glucose disposal within 6?months.