文摘
A new monomer, m-keto acetyl naphthalene acrylic acid (KANAc) was synthesized from reactants of maleic anhydride and 1-acetyl naphthalene. This monomer was polymerized by exposure to γ-rays 60Co. The effects of dose, dose rate, monomer concentration, and temperature on polymerization yield have been investigated. KANAc and its poly(KANAc) were characterized by different techniques. The results indicated that the average molecular weights ranged from 1.1 to 7?×?105 g/mol and having a good stability. The poly(KANAc) has showed broad spectrum antimicrobial activity. Minimal inhibitory concentration (MIC) values ranged from 96 to 186?μg/ml. At MIC and 0.5× MIC concentrations, poly(KANAc) exerted variable effects on 24.4?Gy in vitro γ-irradiated and non-irradiated tested strains. Poly(KANAc) altered cell membrane permeability, induced genomic DNA damage and adverse effects on total protein. Furthermore, it proved to induce in vitro cytotoxicity against different human carcinoma cell lines with 50% inhibitory concentrations (IC50) values in the range of 9.9-2.2?μg/ml. The outcome results have been good and promising in both antimicrobial and antitumoral fields.