Implementation of a vaccine against Shigatoxin 2e in a piglet producing farm with problems of Oedema disease: case study

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• 作者：Regine Fricke ; Olaf Bastert ; Verena Gotter ; Nico Brons…
• 关键词：Oedema disease ; Vaccine ; Reduction of antimicrobial use ; STEC ; EDEC ; Shigatoxin 2e
• 刊名：Porcine Health Management
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：1
• 期：1
• 全文大小：266KB
• 参考文献：1.Martineau GP, Amenna-Bernard N, Waret-Szkuta A: Enfermedad de los edemas: cuadro clinico y lesional y fisiopatologia. Suis 2013, 97: 22鈥?3.
  2.Kempf I, Fleury MA, Drider D, Bruneau M, Sanders P, Chauvin C, et al.: What do we know about resistance to colistin in Enterobacteriaceaein avian and pig production in Europe? Intl J Antimicrob Agents 2013, 42: 379鈥?3. 10.1016/j.ijantimicag.2013.06.012CrossRef
  3.Bednorz C, Oelgeschl盲ger K, Kinnemann B, Hartmann S, Neumann K, Pieper R, et al.: The broader context of antibiotic resistance: zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo. Intl J Medical Microbiol 2013, 303: 396鈥?03. 10.1016/j.ijmm.2013.06.004CrossRef
  4.SDa, Autoriteit Diergeneesmiddelen: Het gebruik van antibiotica bij landbouwhuisdieren in 2013. Utrecht; 2014.
  5.Kamphues J: F眉tterung und Wasserversorgung von Schweinebest盲nden. In Diagnostik und Gesundheitsmanagement im Schweinebestand. Band 1. Edited by: Gro脽e Beilage E, Wendt M. Stuttgart, Deutschland: Eugen Ulmer Verlag; 2013:92鈥?16.
  6.Kim JC, Hansen CF, Mullan BP, Pluske JR: Nutrition and pathology of weaner pigs: Nutritional strategies to support barrier function in the gastrointestinal tract. Anim Feed Sci Technol 2012, 173: 3鈥?6. 10.1016/j.anifeedsci.2011.12.022CrossRef
  7.Coddens A, Verdonck F, Mulinge M, Goyvaerts E, Miry C, Goddeeris B, et al.: The possibility of positive selection for both F18鈥?鈥?/strong> Escherichia coli and stress resistant pigs opens new perspectives for pig breeding. Vet Microbiol 2008, 126: 210鈥?. 10.1016/j.vetmic.2007.06.021PubMed CrossRef
  8.Johansen M, Andresen LO, Jorsal SE, Thomsen LK, Waddell TE, Gyles CL: Prevention of edema disease in pigs by vaccination with verotoxin 2e toxoid. Can J Vet Res 1997, 61: 280鈥?.PubMed Central PubMed
  9.Karg G, Bilkei G: The Effect of Season and Vaccination for Gl盲sser鈥檚 Disease and Post鈥抴eaning Colibacillosis in an Outdoor Pig Unit Endemically Infected with Virulent Strain of Haemophilus Parasuis Serotype 5 and Pathogenic Escherichia coli. J Vet Med Ser B 2002, 49: 464鈥?. 10.1046/j.1439-0450.2002.00587.xCrossRef
  10.Docic M, Bilkei G: Vaccination of weaned pigs against oedema disease. Dtsch tier盲rztl Wochenschrift 2003, 110: 466鈥?.
  11.Bor D, Bilkei G: Effect of vaccination against post-weaning oedema disease on piglet performance. Pig J 2003, 52: 106鈥?0.
  12.Ken C, Bilkei G: Effects of vaccination and of a phytogenic feed additive on postweaning mortality due to Escherichia coli and on piglet performance. Vet Rec 2003, 153: 302鈥?. 10.1136/vr.153.10.302PubMed CrossRef
  13.Starek M, Bilkei G: Prevention of oedema disease in weaned piglets by vaccination. Acta vet Brno 2004, 73: 225鈥?. 10.2754/avb200473020225CrossRef
  14.Bosworth BT, Samuel JE, Moon HW, O鈥橞rien AD, Gordon VM, Whipp SC: Vaccination with genetically modified Shiga-like toxin IIe prevents edema disease in swine. Infect Immun 1996, 64: 55鈥?0.PubMed Central PubMed
  15.Oanh TK, Nguyen VK, de Greve H, Goddeeris BM: Protection of piglets against edema disease by maternal immunization with Stx2e toxoid. Infect Immun 2012, 80: 469鈥?3. 10.1128/IAI.05539-11PubMed Central PubMed CrossRef
  16.L眉der O, Selbitz HJ, Florian V, Fricke RT, Bastert O, Langer O, et al.: Testing of the safety and efficacy of a vaccine containing a genetically modified 鈥楽tx2e鈥?antigen in laboratory and field studies. In Proceedings of the 22nd International Pig Veterinary Society Congress: 10鈥?3 June 2012. Jeju, Korea; 2012:301.
  17.Bastert O, Fricke R, L眉der O: Investigations on a novel vaccine against edema disease in field studies. In Proceedings of the 4th European Symposium of Porcine Health Management: 25鈥?7 April 2012. Bruges, Belgium; 2012:190.
  18.Sidler X, Mattei S, Fricke R, Schmid W, Bastert O, L眉der O, et al.: Results of a field trial for vaccine against Oedema Disease. In Proceedings of the 5th European Symposium of Porcine Health Management: 22鈥?4 May 2013. Edinburgh, United Kingdom; 2013:87.
  19.Johansen M, Fricke R, Bastert O, Friis Nielsen MB, Svensmark B, Haugegaard S, et al.: Successful reduction of mortality by vaccination against Oedema Disease. In Proceedings of the 5th European Symposium of Porcine Health Management: 22鈥?4 May 2013. Edinburgh, United Kingdom; 2013:195.
  20.Lillie-Jaschniski K, K枚chling M, Lindner T: Erste Erfahrungen mit dem Einsatz von ECOPORC SHIGA, der neuen Vakzine gegen die 脰demkrankheit 鈥?Auswertungen aus Feldversuchen in Deutschland. Tier盲rztl Umsch 2013, 68: 377鈥?2.
  21.Palzer A, Becker A: Vaccination against Oedema Disease in a commercial pig farm. In Proceedings of the 5th European Symposium of Porcine Health Management: 22鈥?4 May 2013. Edinburgh, United Kingdom; 2013:104.
  22.Bastert O, Fricke R, Sudendey C, Gnielka D, L眉der O: Effect of vaccination with ECOPORC SHIGA on overall mortality and use of antimicrobial medication due to Edema Disease (ED). In Proceedings of the 5th European Symposium of Porcine Health Management: 22鈥?4 May 2013. Edinburgh, United Kingdom; 2013:143.
  
• 作者单位：Regine Fricke (3)
  Olaf Bastert (3)
  Verena Gotter (3)
  Nico Brons (4)
  Johan Kamp (4)
  Hans-Joachim Selbitz (3)
  
  3. IDT Biologika GmbH, Am Pharmapark, 06861, Dessau-Rosslau, Germany
  4. Dierenkliniek Hellendorn, Ommerweg 54, 7447 RG Hellendoorn-Nijverdal, Kragujevac, Netherlands
  
• 刊物类别：Zoology;
• 刊物主题：Zoology;
• 出版者：BioMed Central
• ISSN：2055-5660

文摘

Oedema disease is one of the major diseases in pigs during the nursery period. It is caused by Shigatoxin 2e producing strains of Escherichia coli. In order to combat the disease, the metaphylactic use of colistin sulphate and zinc oxide is widely spread. Additionally, special feeding regimens such as the reduction of the amount of crude protein and the increase of the amount of crude fibre are applied. The goal of this study was to test the efficacy of a vaccine against Oedema disease caused by Shigatoxin 2e in a field trial on a farm with a history of Oedema disease in nursery pigs. The study was carried out on a Dutch farm with 600 sows and a one-week farrowing rhythm and lasted for the time of one year. During this time all piglets were vaccinated with 1 ml ECOPORC SHIGA at the average age of 4 days. The parameters Overall mortality, use of antimicrobials in general, calculated as defined daily dose per animal, use of colistin sulphate and the weight gain were evaluated for all nursery pigs and compared to historical data of animals from the same period of time directly prior to the study serving as a historical control group. The previous mortality in the nursery of 7.7% was significantly reduced to 1.3% after vaccination. The metaphylactic use of colistin sulphate during the nursery period was stopped during the study because no deaths due to Oedema disease had occurred anymore after beginning of vaccination. The defined daily dose per animal per month was significantly reduced from a mean of 1.050 in the year 2012 to a mean of 0.215 in the year 2013. The defined daily dose per animal per year was therefore relevantly reduced from 12.6 in 2012 to 2.6 in 2013. These results show that on this farm Oedema disease can not only be controlled successfully by vaccination but also that vaccination can significantly reduce the use of antimicrobials in the nursery period. Keywords Oedema disease Vaccine Reduction of antimicrobial use STEC EDEC Shigatoxin 2e