The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer
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- 作者：Chao Zeng (1)
Lili Chen (2)
Zheng Yang (2)
Shijun Sun (3) - 关键词：Heparanase ; COX ; 2 ; VEGF ; C ; Lymphangiogenesis
- 刊名：Medical Oncology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：31
- 期：12
- 全文大小：1,305 KB
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Lili Chen (2)
Zheng Yang (2)
Shijun Sun (3)
1. Department of Pathology, Guangdong Medical College, Dongguan, China
2. Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
3. The Molecular Diagnostic Centre, The Affiliated Zhongshan Hospital of Sun Yat-sen University, Zhongshan, China - ISSN：1559-131X
文摘
Recent observations indicate the vital role of heparanase in tumor lymphangiogenesis. Moreover, heparanase is involved in angiogenesis in esophageal cancer through induction of COX-2. However, it is unclear whether heparanase is also associated with COX-2 in lymphangiogenesis of cervical cancer. In this study, heparanase, COX-2 and VEGF-C expression were examined in 80 cervical cancer cases by immunohistochemical staining. We also studied the correlation of heparanase and COX-2 expression with lymphangiogenesis of cervical cancer quantified as lymphatic vessel density. Our results showed that expressions of heparanase and COX-2 were associated with lymphangiogenesis of cervical cancer. Furthermore, a significant correlation was found between the expression of heparanase and COX-2 (P?COX-2 and VEGF-C. These findings revealed that heparanase may play important function in lymphangiogenesis of cervical cancer via the regulation of COX-2 expression.