A micro-RNA expression signature for human NAFLD progression
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- 作者：Yan Guo ; Yanhua Xiong ; Quanghu Sheng ; Shilin Zhao…
- 关键词：Nonalcoholic fatty liver disease ; NAFLD ; miRNA ; Nonalcoholic steatohepatitis ; NASH ; Hepatocellular carcinoma ; HCC
- 刊名：Journal of Gastroenterology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：51
- 期：10
- 页码：1022-1030
- 全文大小：524 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Gastroenterology
Oncology
Surgical Oncology
Hepatology
Internal Medicine
Colorectal Surgery - 出版者：Springer Japan
- ISSN：1435-5922
- 卷排序：51
文摘
BackgroundThe spectrum of nonalcoholic fatty liver disease (NAFLD) describes disease conditions deteriorating from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to cirrhosis (CIR) to hepatocellular carcinoma (HCC). From a molecular and biochemical perspective, our understanding of the etiology of this disease is limited by the broad spectrum of disease presentations, the lack of a thorough understanding of the factors contributing to disease susceptibility, and ethical concerns related to repeat sampling of the liver. To better understand the factors associated with disease progression, we investigated by next-generation RNA sequencing the altered expression of microRNAs (miRNAs) in liver biopsies of class III obese subjects (body mass index ≥40 kg/m2) biopsied at the time of elective bariatric surgery.