Low Bone Mass is Associated with Stroke in Chinese Postmenopausal Women: The Chongqing Osteoporosis Study

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• 作者：Rui Zhou ; Dong Liu ; Rui Li ; Shiming Zhou ; Min Cui…
• 关键词：Bone mineral density ; Stroke ; Death ; Postmenopausal women
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：71
• 期：3
• 页码：1695-1701
• 全文大小：422 KB
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• 作者单位：Rui Zhou (2)
  Dong Liu (3)
  Rui Li (1)
  Shiming Zhou (1)
  Min Cui (1)
  Lin Chen (3)
  Huadong Zhou (1)
  
  2. Department of Orthopedics, The Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, China
  3. Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
  1. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

The objective of the present study was to investigate the association of low bone mass with the risk of stroke and death in community residents of China. This study was based on the follow-up data acquired from 5,136 postmenopausal women aged 50?years or older between July 2006 and June 2011. Baseline and the follow-up bone mineral density (BMD) in these patients were measured by dual energy X-ray absorptiometry scanning. The association of BMD and risk of stroke and death was further evaluated by Cox proportional hazard analysis. During the follow-up, 148 subjects (2.9?%) sustained prospective stroke, and 261 subjects (5.1?%) died. After adjustments for age and BMI, our results indicated that neck BMD and osteoporosis were independent predictors of stroke (HR for neck BMD?=?1.35, 95?% CI?=?1.21-.62; HR for osteoporosis?=?2.24, 95?% CI?=?1.47-.58) and were also associated with increased risk of death (HR for neck BMD?=?1.39, 95?% CI?=?1.24-.71; HR for osteoporosis?=?1.97, 95?% CI?=?1.21-.97). Our results also suggest that low neck BMD and osteoporosis are associated with significantly elevated risk of stroke and death in Chinese postmenopausal women.