Gut microbiome and metabolic diseases

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• 作者：Shinji Fukuda (1) (2)
  Hiroshi Ohno (2)
  
• 关键词：Gut microbiome ; Metabolic syndrome ; Obesity ; Probiotics ; Omics
• 刊名：Seminars in Immunopathology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：36
• 期：1
• 页码：103-114
• 全文大小：413 KB
• 作者单位：Shinji Fukuda (1) (2)
  Hiroshi Ohno (2)
  
  1. Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan
  2. Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
  
• ISSN：1863-2300

文摘

The prevalence of obesity and obesity-related disorders is increasing worldwide. In the last decade, the gut microbiota has emerged as an important factor in the development of obesity and metabolic syndrome, through its interactions with dietary, environmental, and host genetic factors. Various studies have shown that alteration of the gut microbiota, shifting it toward increased energy harvest, is associated with an obese phenotype. However, the molecular mechanisms by which the gut microbiota affects host metabolism are still obscure. In this review, we discuss the complexity of the gut microbiota and its relationship to obesity and obesity-related diseases. Furthermore, we discuss the anti-obesity potential of probiotics and prebiotics.