Suppression of retinal neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy
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- 作者：Qiong Zhang ; Jingfa Zhang ; Yuan Guan ; Shisheng Zhang ; Caihong Zhu ; Guo-Tong Xu and Ling Wang
- 关键词：VEGF ; iNOS ; Neovascularization ; Aminoguanidine
- 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
- 出版年：2009
- 出版时间：July, 2009
- 年：2009
- 卷：247
- 期：7
- 页码：919-927
- 全文大小：531.1 KB
文摘
Background Retinal neovascularization (NV) is a major cause of blindness associated with ischemic retinal disorders. Our study was focused on evaluating the inhibitory effect of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), on retinal NV in mice of oxygen-induced retinopathy (OIR).