Blood coagulating effect of marigold (Tagetes erecta L.) leaf and its bioactive compounds

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• 作者：Nandita Dasgupta ; Shivendu Ranjan…
• 关键词：Tagetes erecta L ; Response surface methodology ; Coagulation ; Antimicrobial ; Antioxidant ; Antifugal
• 刊名：Oriental Pharmacy and Experimental Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：16
• 期：1
• 页码：67-75
• 全文大小：676 KB
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• 作者单位：Nandita Dasgupta (1)
  Shivendu Ranjan (1) (2)
  Madhu Shree (3)
  M.A. Arabi Mohammed Saleh (4)
  Chidambaram Ramalingam (1)
  
  1. Nano-food Research Group, Instrumental and Food Analysis Laboratory, Industrial Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore, India
  2. Research Wing, Veer Kunwar Singh Memorial Trust, Chapra, Bihar, India, 841301
  3. Department of Zoology, Jai Prakash University, Chapra, Bihar, India
  4. Industrial Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore, India
  
• 刊物主题：Biomedicine general; Pharmacy;
• 出版者：Springer Netherlands
• ISSN：2211-1069

文摘

Marigold (Tagets erecta L.), being an ornamental plant, posses medicinal properties like antimicrobial, insecticidal, wound healing and blood coagulation properties. Our recent works mainly focus on blood clotting activity of marigold leaf extracts. Blood clotting activity of leaf extract was examined using prothrombin time (PT) test by Owren method. The optimization of marigold leaf coagulating activity at different concentration of leaf extract and blood was done with Response surface method (RSM). Experiments showed that there was decrease in coagulation time with increase in extract concentration. Marigold leaves extract has shown very good blood coagulation property in lesser quantity i.e., in the range of μl. Also, phenolic compounds (like gallic acid, scopoletin, ferulic acid, quercecetin) were identified and quantified, which shows that because of presence of them, marigold leaf extract shows coagulation property. Antifungal, antibacterial and antioxidant activity are also analyzed. From the above findings, it can be concluded that along with antibacterial, antifungal and antioxidant properties, marigold leave extracts are also having very good coagulation property; so, in further research it can be developed as an antiseptic with coagulation property and can be developed as a potent product in the field of medicine and ointment.