Competing endogenous RNA interplay in cancer: mechanism, methodology, and perspectives

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• 作者：Dong-Liang Cheng (1)
  Yuan-Yuan Xiang (2)
  Li-juan Ji (3)
  Xiao-Jie Lu (4)
  
  1. Department of Cardiothoracic Surgery ; Shiyan Taihe Hospital ; Hubei University of Medicine ; Shiyan City ; Hubei Province ; China
  2. Cervical disease clinic ; Jiangsu Huai鈥檃n Maternity and Children Hospital ; Huai鈥檃n ; China
  3. Department of Rehabilitation ; The Second People鈥檚 Hospital of Huai鈥檃n ; Huai鈥檃n ; China
  4. Department of Gastroenterology ; Shanghai East Hospital ; Tongji University ; School of Medicine ; Shanghai ; China
  
• 关键词：ceRNA ; Cancer ; miRNA ; miRNA response elements
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：2
• 页码：479-488
• 全文大小：736 KB
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• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Competing endogenous RNAs (ceRNAs) refer to RNA transcripts, such as mRNAs, non-coding RNAs, pseudogene transcripts, and circular RNAs, that can regulate each other by competing for the same pool of miRNAs. ceRNAs involve in the pathogenesis of several common cancers such as prostate cancer, liver cancer, breast cancer, lung cancer, gastric cancer, endometrial cancer, and so on. ceRNA activity is determined by factors such as miRNA/ceRNA abundance, ceRNAs binding affinity to miRNAs, RNA editing, and RNA-binding proteins. The alteration of any of these factors may lead to ceRNA network imbalance and thus contribute to cancer initiation and progression. There are generally three steps in ceRNA research conductions: ceRNA prediction, ceRNA validation, and ceRNA functional investigation. Deciphering ceRNA interplay in cancer provides new insight into cancer pathogenesis and opportunities for therapy exploration. In this review, we try to give readers a concise and reliable illustration on the mechanism, functions, research approaches, and perspective of ceRNA in cancer.