A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
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- 作者：Huan Song ; Xiaoyun He ; Shiying Zou ; Teng Zhang ; Yunbo Luo…
- 关键词：Genetically modified rice ; Cry1Ab ; Safety assessment ; 90 ; Day feeding study ; Rat
- 刊名：Transgenic Research
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：24
- 期：2
- 页码：295-308
- 全文大小：448 KB
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15. Flynn, MM, Reppu - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Molecular Medicine
Plant Genetics and Genomics
Animal Genetics and Genomics
Plant Sciences
Human Genetics - 出版者：Springer Netherlands
- ISSN：1573-9368
文摘
Bacillus thuringiensis (Bt) transgenic rice line (mfb-MH86) expressing a synthetic cry1Ab gene can be protected against feeding damage from Lepidopteran insects, including Sesamia inferens, Chilo suppressalis, Tryporyza incertulas and Cnaphalocrocis medinalis. Rice flour from mfb-MH86 and its near-isogenic control MH86 was separately formulated into rodent diets at concentrations of 17.5, 35 and 70?% (w/w) for a 90-day feeding test with rats, and all of the diets were nutritionally balanced. In this study, the responses of rats fed diets containing mfb-MH86 were compared to those of rats fed flour from MH86. Overall health, body weight and food consumption were comparable between groups fed diets containing mfb-MH86 and MH86. Blood samples were collected prior to sacrifice and a few significant differences (p?0.05) were observed in haematological and biochemical parameters between rats fed genetically modified (GM) and non-GM diets. However, the values of these parameters were within the normal ranges of values for rats of this age and sex, thus not considered treatment related. In addition, upon sacrifice a large number of organs were weighed, macroscopic and histopathological examinations were performed with only minor changes to report. In conclusion, these results demonstrated that no toxic effect was observed in the conditions of the experiment, based on the different parameters assessed. GM rice mfb-MH86 is as safe and nutritious as non-GM rice.