A preliminary report on oral fat tolerance test in rhesus monkeys
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- 作者：Di Wu (1)
Qingsu Liu (2) (3)
Shiyuan Wei (2)
Yu Alex Zhang (1)
Feng Yue (4) - 关键词：Triglyceride ; Lipid metabolism ; Oral fat tolerance test ; Rhesus monkey
- 刊名：Lipids in Health and Disease
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：13
- 期：1
- 全文大小：186 KB
- 作者单位：Di Wu (1)
Qingsu Liu (2) (3)
Shiyuan Wei (2)
Yu Alex Zhang (1)
Feng Yue (4)
1. Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
2. Wincon Laboratory, Wincon TheraCells Biotechnologies Co., Ltd, Nanning, Guangxi Province, 530003, China
3. College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China
4. Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China - ISSN：1476-511X
文摘
Background Oral fat tolerance test (OFTT) has been widely used to assess the postprandial lipemia in human beings, but there is few studies concerning OFTT in nonhuman primates. This study is designed to explore the feasibility of OFTT in rhesus monkeys. Methods In a cross-over study, a total of 8 adult female rhesus monkeys were fed with normal monkey diet (NND), high sugar high fat diet (HHD), and extremely high fat diet (EHD), respectively. Each monkey consumed NND, HHD and EHD respectively, each weighing 60?g. Serial blood samples were collected at 1, 2, 3, 4, 5, and 6?h after ingesting each kind of food. Triglyceride, cholesterol, glucose, and insulin at each time point were measured. The area under the curve of triglyceride (TG-AUC) and triglyceride peak response (TG-PR) were also calculated. Results All monkeys ingested 3 kinds of foods within 15 minutes. TG-AUC and TG-PR of HHD group were higher than those of the other two groups. Postprandial triglyceride levels at 2, 3, 4, and 5 hours in HHD group during OFTT were also higher than those in NND and EHD group. Conclusions HHD diet can be used in OFTT for nonhuman primates.