An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

详细信息    查看全文

• 作者：Xiaobo Li ; Chengcheng Zhang ; Xin Zhang ; Shizhi Wang…
• 关键词：Aluminum oxide nanoparticles ; Mitochondria ; Acetyl ; L ; carnitine ; Nanotoxicology ; Metabolomics
• 刊名：Particle and Fibre Toxicology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：13
• 期：1
• 全文大小：2,335 KB
• 参考文献：1.Mills NL, Donaldson K, Hadoke PW, Boon NA, MacNee W, Cassee FR, et al. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med. 2009;6:36–44.PubMed CrossRef
  2.Lu S, Zhang W, Zhang R, Liu P, Wang Q, Shang Y, et al. Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles. Part Fibre Toxicol. 2015;12:5.PubMed PubMedCentral CrossRef
  3.Huang Y, Lu X, Ma J. Toxicity of silver nanoparticles to human dermal fibroblasts on microRNA level. J Biomed Nanotechnol. 2014;10:3304–17.PubMed CrossRef
  4.Thit A, Selck H, Bjerregaard HF. Toxic mechanisms of copper oxide nanoparticles in epithelial kidney cells. Toxicol In Vitro. 2015;29:1053–9.PubMed CrossRef
  5.Shi Y. A structural view of mitochondria-mediated apoptosis. Nat Struct Biol. 2001;8:394–401.PubMed CrossRef
  6.Xiong S, Mu T, Wang G, Jiang X. Mitochondria-mediated apoptosis in mammals. Protein Cell. 2014;5:737–49.PubMed PubMedCentral CrossRef
  7.Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12:222–30.PubMed PubMedCentral CrossRef
  8.Talla V, Koilkonda R, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, et al. Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE. Invest Ophthalmol Vis Sci. 2015;56:1129–40.PubMed PubMedCentral CrossRef
  9.Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, et al. The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. Mol Cancer. 2013;12:42.PubMed PubMedCentral CrossRef
  10.Fulda S, Galluzzi L, Kroemer G. Targeting mitochondria for cancer therapy. Nat Rev Drug Discov. 2010;9:447–64.PubMed CrossRef
  11.Li R, Kou X, Geng H, Xie J, Tian J, Cai Z, et al. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. J Hazard Mater. 2015;287:392–401.PubMed CrossRef
  12.Stapleton PANC, Yi J, McBride CR, Minarchick VC, Shepherd DL, Hollander JM, et al. Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure. Nanotoxicology. 2014;5:1–11.
  13.Yu KN, Yoon TJ, Minai-Tehrani A, Kim JE, Park SJ, Jeong MS, et al. Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro. 2013;27:1187–95.PubMed CrossRef
  14.Collins FS, Gray GM, Bucher JR. Toxicology. Transforming environmental health protection. Science. 2008;319:906–7.PubMed PubMedCentral CrossRef
  15.Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, et al. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res. 2013;46:607–21.PubMed PubMedCentral CrossRef
  16.Xu B, Chen M, Ji X, Mao Z, Zhang X, Wang X, et al. Metabolomic profiles delineate the potential role of glycine in gold nanorod-induced disruption of mitochondria and blood-testis barrier factors in TM-4 cells. Nanoscale. 2014;6:8265–73.PubMed CrossRef
  17.Hanagata N, Zhuang F, Connolly S, Li J, Ogawa N, Xu M. Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis. ACS Nano. 2011;5:9326–38.PubMed CrossRef
  18.Foldbjerg R, Irving ES, Hayashi Y, Sutherland DS, Thorsen K, Autrup H, et al. Global gene expression profiling of human lung epithelial cells after exposure to nanosilver. Toxicol Sci. 2012;130:145–57.PubMed CrossRef
  19.Shim W, Paik MJ, Nguyen DT, Lee JK, Lee Y, Kim JH, et al. Analysis of changes in gene expression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano. 2012;6:7665–80.PubMed CrossRef
  20.Pettegrew JW, Levine J, McClure RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer’s disease and geriatric depression. Mol Psychiatry. 2000;5:616–32.PubMed CrossRef
  21.Patel SP, Sullivan PG, Lyttle TS, Rabchevsky AG. Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. J Neurochem. 2010;114:291–301.PubMed PubMedCentral
  22.Musicco C, Capelli V, Pesce V, Timperio AM, Calvani M, Mosconi L, et al. Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. Biochim Biophys Acta. 2009;1787:890–6.PubMed CrossRef
  23.Aureli T, Puccetti C, Di Cocco ME, Arduini A, Ricciolini R, Scalibastri M, et al. Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats. Eur J Biochem. 1999;263:287–93.PubMed CrossRef
  24.Annadurai T, Vigneshwari S, Thirukumaran R, Thomas PA, Geraldine P. Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats. J Physiol Biochem. 2011;67:519–30.PubMed CrossRef
  25.Di Cesare ML, Ghelardini C, Calvani M, Nicolai R, Mosconi L, Vivoli E, et al. Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy. Eur J Neurosci. 2007;26:820–7.CrossRef
  26.Dhitavat S, Ortiz D, Shea TB, Rivera ER. Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels. Neurochem Res. 2002;27:501–5.PubMed CrossRef
  27.Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012;18:684–92.PubMed CrossRef
  28.Madl AK, Plummer LE, Carosino C, Pinkerton KE. Nanoparticles, lung injury, and the role of oxidant stress. Annu Rev Physiol. 2014;76:447–65.PubMed PubMedCentral CrossRef
  29.Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, et al. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol. 2008;295:L552–65.PubMed PubMedCentral CrossRef
  30.Sager T, Wolfarth M, Keane M, Porter D, Castranova V, Holian A. Effects of nickel-oxide nanoparticle pre-exposure dispersion status on bioactivity in the mouse lung. Nanotoxicology. 2015;28:1–11.CrossRef
  31.Pisani C, Gaillard JC, Nouvel V, Odorico M, Armengaud J, Prat O. High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16:315.PubMed PubMedCentral CrossRef
  32.Pinkerton KE, Green FH, Saiki C, Vallyathan V, Plopper CG, Gopal V, et al. Distribution of particulate matter and tissue remodeling in the human lung. Environ Health Perspect. 2000;108:1063–9.PubMed PubMedCentral CrossRef
  33.Nymark P, Wijshoff P, Cavill R, van Herwijnen M, Coonen ML, Claessen S, et al. Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells. Nanotoxicology. 2015;9(5):624–35.PubMed
  34.Siddiqui MA, Alhadlaq HA, Ahmad J, Al-Khedhairy AA, Musarrat J, Ahamed M. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PLoS One. 2013;8:e69534.PubMed PubMedCentral CrossRef
  35.Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9:47–59.PubMed CrossRef
  36.Marchi S, Giorgi C, Suski JM, Agnoletto C, Bononi A, Bonora M, et al. Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct. 2012;2012:329635.PubMed PubMedCentral CrossRef
  37.Van Houten B, Woshner V, Santos JH. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst). 2006;5:145–52.
  38.AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano. 2009;3:279–90.PubMed CrossRef
  39.Ahamed M, Akhtar MJ, Raja M, Ahmad I, Siddiqui MK, AlSalhi MS, et al. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine. 2011;7:904–13.PubMed CrossRef
  40.Manke A, Wang L, Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013;2013:942916.PubMed PubMedCentral CrossRef
  41.Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, et al. The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology. Mol Aspects Med. 2011;32:223–33.PubMed CrossRef
  42.Kathirvel E, Morgan K, French SW, Morgan TR. Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. Nutr Res. 2013;33:932–41.PubMed CrossRef
  43.Tong X, Christian P, Zhao M, Wang H, Moreau R, Su Q. Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-alpha-lipoic acid. J Nutr Biochem. 2015;26(9):921–8.PubMed CrossRef
  44.Malaguarnera M. Carnitine derivatives: clinical usefulness. Curr Opin Gastroenterol. 2012;28:166–76.PubMed CrossRef
  45.Cassano P, Sciancalepore AG, Pesce V, Fluck M, Hoppeler H, Calvani M, et al. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. Biochim Biophys Acta. 2006;1757:1421–8.PubMed CrossRef
  46.Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009;34:755–63.PubMed PubMedCentral CrossRef
  47.Vazquez-Memije ME, Capin R, Tolosa A, El-Hafidi M. Analysis of age-associated changes in mitochondrial free radical generation by rat testis. Mol Cell Biochem. 2008;307:23–30.PubMed CrossRef
  48.Roy Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX. Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab. 2010;298:E89–98.PubMed CrossRef
  49.Szapiel SVEN, Fulmer JD, Hunninghake GW, Crystal RG. Bleomycin-induced interstitial pulmonary diseases in the nude, athymic mouse. Am Rev Resp Dis. 1979;120:7.
  
• 作者单位：Xiaobo Li (1)
  Chengcheng Zhang (1)
  Xin Zhang (1)
  Shizhi Wang (1)
  Qingtao Meng (1)
  Shenshen Wu (1)
  Hongbao Yang (2)
  Yankai Xia (3)
  Rui Chen (1) (4)
  
  1. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Dingjiaqiao 87, Nanjing, 210009, China
  2. Center for Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China
  3. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
  4. State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China
  
• 刊物主题：Pharmacology/Toxicology; Pneumology/Respiratory System; Nanotechnology and Microengineering;
• 出版者：BioMed Central
• ISSN：1743-8977

文摘

Background Due to the wide application of engineered aluminum oxide nanoparticles and increased aluminum containing particulate matter suspending in air, exposure of human to nano-scale aluminum oxide nanoparticles (Al₂O₃ NPs) is becoming inevitable.