Tramadol/acetaminophen causes constipation more frequently in women with degenerative spinal disorders than in those with degenerative joint disorders

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• 作者：Mikio Kamimura (2)
  Yukio Nakamura (1)
  Shota Ikegami (1)
  Akira Ichinose (3)
  Shigeharu Uchiyama (1)
  Hiroyuki Kato (1)
  
• 刊名：Drugs & Therapy Perspectives
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：30
• 期：4
• 页码：149-154
• 全文大小：277 KB
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• 作者单位：Mikio Kamimura (2)
  Yukio Nakamura (1)
  Shota Ikegami (1)
  Akira Ichinose (3)
  Shigeharu Uchiyama (1)
  Hiroyuki Kato (1)
  
  2. Center of Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan
  1. Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan
  3. Ichinose Clinic, Nishitakano-machi, Shimosuwa-machi, Nagano, Japan
  
• ISSN：1179-1977

文摘

Background Chronic pain, a challenging issue worldwide, requires better treatment. Objective and Study design In this prospective, open-label study, we examined the frequency of adverse effects associated with treatment with a fixed-dose combination of tramadol/acetaminophen 37.5/325?mg following gradually increased administration in outpatients with chronic musculoskeletal pain (focusing on degenerative spinal disorders and degenerative joint disorders). In all cases, tramadol/acetaminophen administration reached a plateau within 2?months and the frequency of adverse events were evaluated at that time. Results and Conclusion Patients with degenerative spinal disorders had significantly higher rates of overall adverse events and constipation (the most common adverse event) than patients with joint disorders.