Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells

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• 作者：Shuai Gao ; Li Tao ; Xinfeng Hou ; Zijian Xu ; Wenqiang Liu…
• 关键词：Hematopoietic progenitor and stem cells ; Induced pluripotent stem cells ; Pluripotency ; Reprogramming
• 刊名：Stem Cell Research & Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：1
• 全文大小：1,655 KB
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Background Transcription factor-mediated reprogramming can efficiently convert differentiated cells into induced pluripotent stem cells (iPSCs). Furthermore, many cell types have been shown to be amenable to reprogramming into iPSCs, such as neural stem cells, hematopoietic progenitor and stem cells (HPC/HSCs). However, the mechanisms related to the amenability of these cell types to be reprogrammed are still unknown.