Characterization of a shorter recombinant polypeptide chain of bone morphogenetic protein 2 on osteoblast behaviour
详细信息 查看全文
- 作者：Yufeng Zhang ; Yang Shuang ; Hang Fu ; Wei Zhou ; Li Qian ; Jing Dai…
- 关键词：BMP2 ; Osteoinductive ; Osteoinduction ; Osteoblast differentiation ; Guided bone regeneration
- 刊名：BMC Oral Health
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：2,120 KB
- 刊物主题：Dentistry; Oral and Maxillofacial Surgery;
- 出版者：BioMed Central
- ISSN：1472-6831
文摘
Background Recombinant bone morphogenetic protein two (rhBMP2) has been utilised for a variety of clinical applications in orthopaedic surgery and dental procedures. Despite its widespread use, concerns have been raised regarding its short half-life and transient bioactivity in vivo. Recent investigation aimed at developing rhBMP2 synthesized from a shorter polypeptide chain (108 amino acids) has been undertaken.