Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

详细信息    查看全文

• 作者：Da-Song Yang ; Shuang-Mei Wang ; Wei-Bing Peng…
• 关键词：Macaranga adenantha ; Prenylated Flavonoids ; Macadenanthins A–C ; Cytotoxicity
• 刊名：Natural Products and Bioprospecting
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：5
• 期：2
• 页码：105-109
• 全文大小：335 KB
• 参考文献：1.B. Botta, A. Vitali, P. Menendez, D. Misiti, G.D. Monache, Curr. Med. Chem. 12, 713-39 (2005)View Article
  2.J.J. Magadula, J. Med. Plants. Res. 8, 489-03 (2014)View Article
  3.M. Ma, Dissertation, Peking Union Medical College, 2003
  4.M. Ma, X.Y. Shang, S.J. Wang, S. Li, Y.C. Yang, J.G. Shi, China J. Chin. Mater. Med. 32, 1175-179 (2007)
  5.M. Ma, S.J. Wang, S. Li, Y.C. Yang, J.G. Shi, F. Ye, J.Y. Tian, Chin. Tradit. Herb. Drugs. 37, 1128-131 (2006)
  6.D.S. Yang, J.G. Wei, W.B. Peng, S.M. Wang, C. Sun, Y.P. Yang, K.C. Liu, X.L. Li, Fitoterapia 99, 261-66 (2014)View Article PubMed
  7.J.G. Wei, D.S. Yang, Y.P. Yang, Y.Y. Wang, X.L. Li, Nat. Prod. Res. Dev. 26, 1789-792 (2014)
  8.D.S. Yang, Z.L. Li, X. Wang, H. Yan, Y.P. Yang, H.R. Luo, K.C. Liu, W.L. Xiao, X.L. Li, RSC Adv. 5, 13886-3890 (2015)View Article
  9.L. Zeng, T. Fukai, T. Nomura, R.Y. Zhang, Z.C. Lou, Heterocycles 34, 575-87 (1992)View Article
  10.D.S. Yang, J.C. Yang, Y.P. Yang, X.F. Yang, X.L. Li, Chin. Tradit. Herb. Drugs. 45, 3520-523 (2014)
  11.E. Hnawia, O. Thoison, F. Guéritte-Voegelein, D. Bourret, T. Sévenet, Phytochemistry 29, 2367-368 (1990)View Article
  12.T.K. Tabopda, J. Ngoupayo, P.K. Awoussong, A.C. Mitaine-Offer, M.S. Ali, B.T. Ngadjui, M.A. Lacaille-Dubois, J. Nat. Prod. 71, 2068-072 (2008)View Article PubMed
  13.Q. Jin, C. Lee, J.W. Lee, E.T. Yeon, D. Lee, S.B. Han, J.T. Hong, Y. Kim, M.K. Lee, B.Y. Hwang, J. Nat. Prod. 77, 1724-728 (2014)View Article PubMed
  14.T. Hatano, M. Takagi, H. Ito, T. Yoshida, Chem. Pharm. Bull. 45, 1485-492 (1997)View Article
  15.D.S. Yang, W.B. Peng, Z.L. Li, X. Wang, J.G. Wei, Q.X. He, Y.P. Yang, K.C. Liu, X.L. Li, Fitoterapia 97, 211-18 (2014)View Article PubMed
  
• 作者单位：Da-Song Yang (1)
  Shuang-Mei Wang (1)
  Wei-Bing Peng (2)
  Yong-Ping Yang (1)
  Ke-Chun Liu (2)
  Xiao-Li Li (1)
  Wei-Lie Xiao (3)
  
  1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People’s Republic of China
  2. Biology Institute of Shandong Academy of Sciences, Jinan, 250014, People’s Republic of China
  3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People’s Republic of China
  
• 刊物主题：Plant Biochemistry; Bioorganic Chemistry; Medicinal Chemistry; Pharmacology/Toxicology; Plant Sciences; Food Science;
• 出版者：Springer Berlin Heidelberg
• ISSN：2192-2209

文摘

Three new minor prenylated flavonoids, named macadenanthins A–C (1-strong class="EmphasisTypeBold">3), together with three known ones (4-strong class="EmphasisTypeBold">6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-strong class="EmphasisTypeBold">3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC₅₀ values in the range of 13.76-2.27?μM.