Spin probes for electron paramagnetic resonance imaging
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- 作者：GuoPing Yan (1)
Lei Peng (1)
ShuangQuan Jian (1)
Liang Li (1)
Steven Eric Bottle (2) - 关键词：electron paramagnetic resonance imaging (EPRI) ; spin probes ; deuterated ; site ; specific and macromolecular ntroxides
- 刊名：Chinese Science Bulletin
- 出版年：2008
- 出版时间：December 2008
- 年：2008
- 卷：53
- 期：24
- 页码：3777-3789
- 全文大小：602KB
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Lei Peng (1)
ShuangQuan Jian (1)
Liang Li (1)
Steven Eric Bottle (2)
1. School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan, 430073, China
2. School of Physical and Chemical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, Q4001, Australia - ISSN：1861-9541
文摘
Electron paramagnetic resonance imaging (EPRI) is a relatively recent imaging technique, which provides potentially multidimensional imaging of the spatial distribution of paramagnetic species. Thanks to the use of stable spin probes, low frequency EPR imaging has recently allowed the use of large tissue samples or whole animals in vivo in the field of biology and medicine. It is normally necessary to introduce prior intravenous or intramuscular infusion of stable or slowly metabolizable non-toxic water-soluble paramagnetic materials, or stable implantable particulate materials as spin probes into the system. The classification and research progress of spin probes at present were described briefly. Three important potential approaches in water-soluble paramagnetic materials design including deuterated, site-specific and macromolecular conjugated nitroxides were also investigated.