The antibacterial peptide ABP-CM4: the current state of its production and applications

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• 作者：Jian Feng Li (1)
  Jie Zhang (1)
  Xing Zhou Xu (1)
  Yang Yang Han (1)
  Xian Wei Cui (1)
  Yu Qing Chen (1)
  Shuang Quan Zhang (1234) shuangquanz@yahoo.com
• 关键词：Antibacterial peptide – ; ABP ; CM4 – ; Heterologous expression – ; Antimicrobial – ; Anticancer
• 刊名：Amino Acids
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：42
• 期：6
• 页码：2393-2402
• 全文大小：745.5 KB
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• 作者单位：1. Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Life Science College, Nanjing Normal University, 210046 Nanjing, Jiangsu, People鈥檚 Republic of China2. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, 210046 Nanjing, People鈥檚 Republic of China3. Jiangsu Key Laboratory for Aquatic Crustacean Diseases, Nanjing Normal University, 210046 Nanjing, People鈥檚 Republic of China4. Jiangsu Key Laboratory for Supermolecular Medicinal Materials and Applications, Nanjing Normal University, 210046 Nanjing, People鈥檚 Republic of China
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Analytical Chemistry
  Biochemical Engineering
  Life Sciences
  Proteomics
  Neurobiology
  
• 出版者：Springer Wien
• ISSN：1438-2199

文摘

The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous efforts to develop new antibiotics with new modes of actions. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi, and tumor cells, which may possibly be used as a promising candidate for a new antibiotic. For pharmaceutical applications, a large quantity of antimicrobial peptides needs to be produced economically. In this communication, the progress in the structural characteristics, heterologous production, and biological evaluation of ABP-CM4 are reviewed.