Peptide regulation of metabolic processes under hypercholesterinemia conditions of an organism

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• 作者：L. A. Lyapina ; M. E. Grigor’eva ; T. Yu. Obergan ; T. A. Shubina…
• 刊名：Biology Bulletin
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：42
• 期：6
• 页码：546-555
• 全文大小：219 KB
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• 作者单位：L. A. Lyapina (1)
  M. E. Grigor’eva (1)
  T. Yu. Obergan (1)
  T. A. Shubina (1)
  L. A. Andreeva (2)
  N. F. Myasoedov (2)
  
  1. Moscow State University, Faculty of Biology, Moscow, 119991, Russia
  2. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 2, Moscow, 123182, Russia
  
• 刊物主题：Life Sciences, general; Cell Biology; Biochemistry, general; Zoology; Ecology;
• 出版者：Springer US
• ISSN：1608-3059

文摘

The participation of short glyproline peptides in regulating the metabolic processes of the body has been established. Experimental hypercholesterolemia and the development of metabolic syndrome in rats was caused by including foods with excess animal fat and carbohydrates in the diet, which eventually led to increased levels of cholesterol, triglycerides, and the atherogenic lipoproteins; hypercoagulation; and increased blood sugar. It was noted that glyprolines with different structures possess a unique combined effect on fat and carbohydrate metabolism, normalizing the characteristics of the lipid profile and blood sugar and protecting the organisms of animals from increased blood clotting. The idea of peptide regulation of the hemostatic system and metabolism of fats and carbohydrates in the development of metabolic syndrome was formulated. Original Russian Text ? L.A. Lyapina, M.E. Grigor’eva, T.Yu. Obergan, T.A. Shubina, L.A. Andreeva, N.F. Myasoedov, 2015, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2015, No. 6, pp. 634-44.