Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia
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- 作者：Xuanyao Liu (1)
Yushimah Yunus (2)
Dongsheng Lu (3)
Farhang Aghakhanian (4)
Woei-Yuh Saw (5) (6)
Lian Deng (3)
Mohammad Ali (5)
Xu Wang (6)
Fadzilah Ghazali (7)
Thuhairah Abdul Rahman (7)
Shahrul Azlin Shaari (7)
Mohd Zaki Salleh (8)
Maude E. Phipps (4)
Rick Twee-Hee Ong (6)
Shuhua Xu (3)
Yik-Ying Teo (1) (10) (5) (6) (9)
Boon-Peng Hoh (2)
1. NUS Graduate School for Integrative Science and Engineering ; National University of Singapore ; Singapore ; 117456 ; Singapore
2. Institute of Medical Molecular Biotechnology ; Faculty of Medicine ; Universiti Teknologi MARA ; Sungai Buloh Campus ; Jalan Hospital ; 47000 ; Sungai Buloh ; Selangor ; Malaysia
3. Max Planck Independent Research Group on Population Genomics ; Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology ; Shanghai Institutes for Biological Sciences ; Chinese Academy of Sciences Shanghai ; Shanghai ; China
4. Jeffrey Cheah School of Medicine and Health Sciences ; Monash University Sunway Campus ; Subang Jaya ; Selangor ; Malaysia
5. Life Sciences Institute ; National University of Singapore ; Singapore ; Singapore
6. Saw Swee Hock School of Public Health ; National University of Singapore ; Singapore ; 117597 ; Singapore
7. Clinical Pathology Diagnostic Centre Research Laboratory ; Faculty of Medicine ; Universiti Teknologi MARA ; Sungai Buloh Campus ; Sungai Buloh ; Selangor ; Malaysia
8. Integrative Pharmacogenomics Institute ; Universiti Teknologi MARA ; 42300 ; Puncak Alam ; Selangor ; Malaysia
10. Genome Institute of Singapore ; Agency for Science ; Technology and Research ; Singapore ; 138672 ; Singapore
9. Department of Statistics and Applied Probability ; National University of Singapore ; Singapore ; Singapore - 刊名：Human Genetics
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：134
- 期：4
- 页码：375-392
- 全文大小：2,142 KB
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- 刊物主题：Biomedicine
Human Genetics
Molecular Medicine
Internal Medicine
Metabolic Diseases - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1203
文摘
The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.