Conceptual structure of the Taiwan Chinese version of the EORTC QLQ-C30

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• 作者：Chi-Cheng Huang ; Shih-Hsin Tu ; Heng-Hui Lien ; Ching-Shui Huang…
• 关键词：Quality of life ; EORTC QLQ ; C30 ; Taiwan Chinese ; Cancer ; Conceptual structure ; Higher ; order factor
• 刊名：Quality of Life Research
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：24
• 期：8
• 页码：1999-2013
• 全文大小：1,904 KB
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• 作者单位：Chi-Cheng Huang (1) (2) (3)
  Shih-Hsin Tu (3) (4)
  Heng-Hui Lien (2) (4)
  Ching-Shui Huang (3) (4)
  Pa-Chun Wang (5)
  Wei-Chu Chie (6)
  
  1. Cathay General Hospital SiJhih, New Taipei City, Taiwan
  2. School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
  3. School of Medicine, Taipei Medical University, Taipei City, Taiwan
  4. Department of Surgery, Cathay General Hospital, Taipei City, Taiwan
  5. Quality Management Center, Cathay General Hospital, Taipei City, Taiwan
  6. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Quality of Life Research
  Sociology
  Public Health
  
• 出版者：Springer Netherlands
• ISSN：1573-2649

文摘

Objective This study aimed to evaluate the conceptual structure of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) by analyzing data collected from patients with major cancers in Taiwan. The conceptual structure underlying QLQ-C30, including higher-order factors, was explored by structural equation modeling (SEM). Methods The Taiwan Chinese version of the EORTC QLQ-C30 was used as the measuring instrument. Higher-order models, including mental health/physical health, mental function/physical burden, symptom burden/function, single latent health-related quality of life, formative symptom burden/function, and formative health-related quality of life, were tested. Results Study subjects included 283 patients with breast, lung, and nasopharyngeal cancers. The original QLQ-C30 multi-factorial structure demonstrated poor composite reliability of the cognitive function subscale. The formative symptom/burden model was favored by model fit indices, further supporting causal–indicator duality, but was compromised by unexpected associations between symptomatic subscales and latent factors. The formative health-related quality of life was proposed with a single second-order latent factor where symptomatic subscales remained formative. Two additional symptom measures from the formal cognitive function subscale with the formative health-related quality-of-life model were proposed as the alterative conceptual structure for the Taiwan Chinese QLQ-C30. Conclusions Results of the current study represent the complete SEM approach for the EORTC QLQ-C30. The formative health-related quality-of-life model with elimination of cognitive function enhances the conceptual structure of the Taiwan Chinese version with parsimonious fit and interpretability.