T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease

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• 作者：Shui-Yi Hu ; Xiao-Yu Jia ; Jian-Nan Li ; Xin Zheng ; Jie Ao…
• 关键词：anti ; GBM disease ; T cell ; IL ; 17 ; CD8 ; kidney injury
• 刊名：Science China Life Sciences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：12
• 页码：1282-1289
• 全文大小：1087KB
• 刊物主题：Life Sciences, general;
• 出版者：Science China Press
• ISSN：1869-1889
• 卷排序：59

文摘

Cell-mediated autoimmunity, particularly that involving autoreactive T cells, participates in mediating anti-glomerular basement membrane (GBM) disease. However, direct kidney injury mediated by renal infiltrated T cells has not been clearly elucidated in humans. The T cell profile (CD3, CD4, CD8, IL-17, and foxp3) and macrophage (CD68) were examined by immunohistochemistry on renal biopsy tissues from 13 patients with anti-GBM disease. The correlation between cell infiltration and clinical data was also analyzed. We found that the distribution of T cell infiltration was predominant in the peri-glomerular and interstitial areas. CD3+ T cell infiltratrion around the glomeruli with cellular crescent formations was significantly higher than that around the glomeruli with mild mesangial proliferation. CD8+ T cells significantly accumulated around the glomeruli with cellular crescents without IgG deposits compared to those with IgG deposits. The prevalence of infiltrating CD8+ T cells was correlated with the percentage of ruptured Bowman’s capsules. In conclusion, cellular immunity may play a crucial role in the inflammatory kidney injury in anti-GBM patients. The periglomerular infiltration of T cells, especially CD8+ T cells, may participate in the pathogenic mechanism of glomerular damage.