p120ctn isoform 1 expression significantly correlates with abnormal expression of E-cadherin and poor survival of lung cancer patients

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• 作者：Yuan Miao (1)
  Nan Liu (1)
  Yong Zhang (1)
  Yang Liu (1)
  Juan-Han Yu (1)
  Shun-Dong Dai (1)
  Hong-Tao Xu (1)
  En-Hua Wang (1)
  
• 关键词：p120ctn ; p120 isoforms ; E ; cadherin ; Lung cancer ; Prognosis
• 刊名：Medical Oncology
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：27
• 期：3
• 页码：880-886
• 全文大小：807KB
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• 作者单位：Yuan Miao (1)
  Nan Liu (1)
  Yong Zhang (1)
  Yang Liu (1)
  Juan-Han Yu (1)
  Shun-Dong Dai (1)
  Hong-Tao Xu (1)
  En-Hua Wang (1)
  
  1. Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, 110001, Shenyang, China
  

文摘

Different p120ctn isoforms exert different, even opposing, effects on tumor cell growth depending on the level of E-cadherin expression, but the impact on clinicopathological parameters of lung cancer patients is not clear. Herein, we investigate the correlation between pan-p120ctn, p120ctn isoform 1, and E-cadherin expression and clinicopathological parameters, especially prognosis, of lung cancer patients. Immunohistochemistry on 20 specimens of normal bronchial epthelium revealed that, p120ctn isoform 1 was not expressed at the membrane; only weak cytoplasmic expression was seen. In contrast, both pan-p120ctn and E-cadherin were expressed clearly on the cell membrane or in the cytoplasmic peri-membrane region. However, in squamous cell lung cancer or lung adenocarcinomas, p120ctn isoform 1 over-expressed in the cytoplasm accompany with the abnormal pan-p120ctn and E-cadherin cytoplasm expression. p120ctn isoform 1 over-expression correlated positively with lymph node metastasis, poor differentiation, histological type, and high TNM stage. Cytoplasmic p120ctn isoform 1 expression in metastatic nodules was always higher than in the primary tumor. While the mean survival times of patients with normal p120 ctn isoform 1 or pan-p120ctn expression differed significantly, the mean survival times of patients with abnormal expression were similar. Lymph node metastasis, TNM stage, abnormal pan-p120ctn expression, and p120ctn isoform 1 over-expression were all independent factors affecting the prognosis of lung cancer patients. Over-expression of p120ctn isoform 1 positively correlated with poor prognosis of lung cancer patients, and therefore may be a useful marker of lung cancer patient survival.