Circulating interleukin-1β promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2

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• 作者：Zhongwei Liu ; Na Zhao ; Huolan Zhu ; Shunming Zhu ; Shuo Pan…
• 关键词：Diabetic cardiomyopathy ; Endoplasmic reticulum stress ; Apoptosis ; IL ; 1 ; IRAK ; 2
• 刊名：Cardiovascular Diabetology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：14
• 期：1
• 全文大小：4,244 KB
• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840

文摘

Aim IL-1β was considered as an important inflammatory cytokine in diabetic cardiovascular complications. DCM is one of the major manifestations of diabetic cardiovascular complications whose specific mechanisms are still unclear. In this study, we investigated the role of IL-1β in myocytes apoptosis in DCM.