Prevalence and the long-term prognosis of functional mitral regurgitation in Japanese patients with symptomatic heart failure

详细信息    查看全文

• 作者：Hidehiro Kaneko (1)
  Shinya Suzuki (1)
  Tokuhisa Uejima (1)
  Hiroto Kano (1)
  Shunsuke Matsuno (1)
  Takayuki Otsuka (1)
  Hideaki Takai (1)
  Yuji Oikawa (1)
  Junji Yajima (1)
  Akira Koike (1)
  Kazuyuki Nagashima (1)
  Hajime Kirigaya (1)
  Koichi Sagara (1)
  Hiroaki Tanabe (1)
  Hitoshi Sawada (1)
  Tadanori Aizawa (1)
  Takeshi Yamashita (1)
  
• 关键词：Functional mitral regurgitation ; Heart failure ; Prognosis ; Japanese
• 刊名：Heart and Vessels
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：29
• 期：6
• 页码：801-807
• 全文大小：458 KB
• 参考文献：1. Koelling TM, Aaronson KD, Cody RJ, Bach DS, Armstrong WF (2002) Prognostic significance of mitral regurgitation and tricuspid regurgitation in patients with left ventricular systolic dysfunction. Am Heart J 144:524-29 CrossRef
  2. Trichon BH, Felker GM, Shaw LK, Cabell CH, O’Connor CM (2003) Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure. Am J Cardiol 91:538-43 CrossRef
  3. Dickstein K, Vardas PE, Auricchio A, Daubert JC, Linde C, McMurray J, Ponikowski P, Priori SG, Sutton R, van Veldhuisen DJ (2010) 2010 focused update of ESC guidelines on device therapy in heart failure: an update of the 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J 31:2677-687 CrossRef
  4. Di Biase L, Auricchio A, Mohanty P, Bai R, Kautzner J, Pieragnoli P, Regoli F, Sorgente A, Spinucci G, Ricciardi G, Michelucci A, Perrotta L, Faletra F, Mlcochova H, Sedlacek K, Canby R, Sanchez JE, Horton R, Burkhardt JD, Moccetti T, Padeletti L, Natale A (2011) Impact of cardiac resynchronization therapy on the severity of mitral regurgitation. Europace 13:829-38 CrossRef
  5. Rossi A, Dini FL, Faggiano P, Agricola E, Cicoira M, Frattini S, Simioniuc A, Gullace M, Ghio S, Enriquez-Sarano M, Temporelli PL (2011) Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart 97:1675-680 CrossRef
  6. Shiba N, Shimokawa H (2008) Chronic heart failure in Japan: implications of the CHART studies. Vasc Health Risk Manag 4:103-13 CrossRef
  7. Tsutsui H, Tsuchihashi M, Takeshita A (2001) Mortality and readmission of hospitalized patients with congestive heart failure and preserved versus depressed systolic function. Am J Cardiol 88:530-33 CrossRef
  8. Ramadan MM, Okura Y, Ohno Y, Suzuki K, Taneda K, Hoyano M, Hao K, Kimura S, Kodama M, Aizawa Y (2008) Comparative analysis of systolic and isolated diastolic dysfunction: Sado heart failure study. Int Heart J 49:459-69 CrossRef
  9. Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Yokota T, Goto D, Yokoshiki H, Kato N, Takeshita A, Tsutsui H (2009) Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. Report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD). Circ J 73:1893-900 CrossRef
  10. Kaneko H, Koike A, Senoo K, Tanaka S, Suzuki S, Nagayama O, Sagara K, Otsuka T, Matsuno S, Funada R, Uejima T, Oikawa Y, Yajima J, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T (2012) Role of cardiopulmonary dysfunction and left atrial remodeling in development of acute decompensated heart failure in chronic heart failure with preserved left ventricular ejection fraction. J Cardiol 59:359-65 CrossRef
  11. Kaneko H, Yajima J, Oikawa Y, Tanaka S, Fukamachi D, Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T (2013) Obesity paradox in Japanese patients after percutaneous coronary intervention: an observation cohort study. J Cardiol 16:18-7 CrossRef
  12. Kaneko H, Suzuki S, Yajima J, Oikawa Y, Sagara K, Otsuka T, Matsuno S, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T (201
• 作者单位：Hidehiro Kaneko (1)
  Shinya Suzuki (1)
  Tokuhisa Uejima (1)
  Hiroto Kano (1)
  Shunsuke Matsuno (1)
  Takayuki Otsuka (1)
  Hideaki Takai (1)
  Yuji Oikawa (1)
  Junji Yajima (1)
  Akira Koike (1)
  Kazuyuki Nagashima (1)
  Hajime Kirigaya (1)
  Koichi Sagara (1)
  Hiroaki Tanabe (1)
  Hitoshi Sawada (1)
  Tadanori Aizawa (1)
  Takeshi Yamashita (1)
  
  1. The Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-ku, Tokyo, 106-0031, Japan
  
• ISSN：1615-2573

文摘

Functional mitral regurgitation (FMR) is a common and critical condition in patients with heart failure (HF); however, the prevalence and clinical outcome of FMR in Japanese real-world clinical practice remain unclear. Within a single hospital-based cohort in the Shinken Database 2004-011, which comprised all new patients (n = 17,517) who visited the Cardiovascular Institute, we followed symptomatic HF patients. A total of 1,701 patients were included: 104 FMR patients (who had moderate to severe FMR) and 1,597 non-FMR patients (who had none or mild FMR). FMR patients had lower rates of hypertension and dyslipidemia, but higher rates of dilated cardiomyopathy, atrial fibrillation, and New York Heart Association functional class III/IV. FMR patients had higher levels of brain natriuretic peptide and lower left ventricular function. Use of cardiovascular drugs was more common among FMR patients. Kaplan–Meier curves revealed that the incidences of all-cause death, cardiovascular death, and admission for HF were significantly higher in FMR patients. The adjusted Cox regression analysis showed that significant FMR was associated with higher incidences of all-cause death [hazard ratio (HR) 2.179, 95 % confidence interval (CI) 1.266-.751; P = 0.005], cardiovascular death (HR 2.371, 95 % CI 1.157-.858; P = 0.018), and admission for HF (HR 1.819, 95 % CI 1.133-.920; P = 0.013). FMR was common in Japanese symptomatic HF patients and was associated with adverse long-term outcomes. Establishing optimal therapeutic strategies for FMR is warranted.