DNA sensor cGAS-mediated immune recognition
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- 作者：Pengyan Xia ; Shuo Wang ; Pu Gao ; Guangxia Gao ; Zusen Fan
- 关键词：cGAS ; cGAMP ; innate immunity ; cytosolic DNAs ; DNA sensors
- 刊名：Protein & Cell
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：7
- 期：11
- 页码：777-791
- 全文大小：2,015 KB
- 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1674-8018
- 卷排序：7
文摘
The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.