Acteoside reduces testosterone by inhibiting cAMP, p450scc, and StAR in rat Leydig cells

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• 作者：Shuqiang Liu (1)
  Junwen Zhang (2)
  Weixuan Li (2)
  Tianxiang Zhang (2)
  Defu Hu (1)
  
  1. College of Nature Conservation ; Beijing Forestry University ; Beijing ; People鈥檚 Republic of China
  2. College of Biological Science and Technology ; Beijing Forestry University ; Beijing ; People鈥檚 Republic of China
  
• 关键词：Acteoside ; cAMP ; p450scc ; StAR ; Testosterone ; Leydig cells
• 刊名：Molecular & Cellular Toxicology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：11
• 期：1
• 页码：11-17
• 全文大小：536 KB
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• 刊物主题：Cell Biology; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：2092-8467

文摘

The present study investigated the in vivo and in vitro effects of acteoside on testosterone production in Sprague-Dawley (SD) rats. The in vivo experiment revealed that acteoside reduced the testosterone level in serum significantly (Pin vitro experiment also illustrated that acteoside significantly reduced testosterone production in SD rat Leydig cells in primary culture (PEnzyme-linked immunosorbent assay results demonstrated that acteoside significantly reduced the cyclic adenosine 3', 5'-monophosphate (cAMP) level (PPcAMP, p450scc, and StAR, but not apoptosis.