Estimation of Trace Elements in Mace (Myristica fragrans Houtt) and Their Effect on Uterine Cervix Cancer Induced by Methylcholanthrene

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• 作者：Chunjing Zhang (1)
  Xiaodan Qi (2)
  Yan Shi (1)
  Yan Sun (3)
  Shuyan Li (1)
  Xiulan Gao (4)
  Haitao Yu (5)
  
• 关键词：Mace ; Trace elements ; Methylcholanthrene ; Uterine cervical cancer ; AAS
• 刊名：Biological Trace Element Research
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：149
• 期：3
• 页码：431-434
• 全文大小：123KB
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• 作者单位：Chunjing Zhang (1)
  Xiaodan Qi (2)
  Yan Shi (1)
  Yan Sun (3)
  Shuyan Li (1)
  Xiulan Gao (4)
  Haitao Yu (5)
  
  1. Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, 161006, People’s Republic of China
  2. Department of Clinical Biochemistry, Qiqihar Medical University, Qiqihar, 161006, People’s Republic of China
  3. Department of Clinical Pathogenic Microorganism, Qiqihar Medical University, Qiqihar, 161006, People’s Republic of China
  4. Shandong College of Chinese Medicine, Yantai, Shandong, 265200, People’s Republic of China
  5. Department of Biology Genetics, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of China
  

文摘

In the present work, trace elemental analysis of mace (Myristica fragrans Houtt) was carried out by the atomic absorption spectrometry technique. The concentrations of various elements analyzed in this medicine were ranked in decreasing order: selenium (Se)-gt;?zinc (Zn)-gt;?magnesium (Mg)-gt;?iron (Fe)-gt;?calcium (Ca)-gt;?manganese (Mn)-gt;?lead (Pb). The concentrations of Mg, Zn, Fe, Mn, Ca, and Se were significantly decreased in serum of methylcholanthrene tumor models (P-lt;-.001) compared with the control and mace groups. It is consistent with the result of tumor incidence. These trace elements could be directly or indirectly responsible for the antitumor activity of mace. The inorganic elements in this folk remedy can partly account for the antitumor.