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1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan 2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tz-You 1st Road, 807, Kaohsiung, Taiwan 3. Department of Public Health, College of Health Science, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan 4. Center of Excellence for Environmental Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan 5. Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, No. 482, Shanming Rd, Hsiaogang District, 812, Kaohsiung, Taiwan 6. Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan 7. Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan 8. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tz-You 1st Road, 807, Kaohsiung, Taiwan 9. Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan