Survival impact of serum uric acid levels in children and adolescents

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• 作者：Shao-Hsuan Hsia (1)
  I-Jun Chou (2) (3)
  Chang-Fu Kuo (4)
  Lai-Chu See (5) (6)
  Jing-Long Huang (7)
  Kuang-Hui Yu (4)
  Shue-Fen Luo (4)
  Chang-Teng Wu (2)
  Kuang-Lin Lin (3)
  Huei-Shyong Wang (3)
  
• 关键词：Uric acid ; Mortality ; Children and adolescents ; Cardiovascular diseases
• 刊名：Rheumatology International
• 出版年：2013
• 出版时间：November 2013
• 年：2013
• 卷：33
• 期：11
• 页码：2797-2802
• 全文大小：en>
• 作者单位：Shao-Hsuan Hsia (1)
  I-Jun Chou (2) (3)
  Chang-Fu Kuo (4)
  Lai-Chu See (5) (6)
  Jing-Long Huang (7)
  Kuang-Hui Yu (4)
  Shue-Fen Luo (4)
  Chang-Teng Wu (2)
  Kuang-Lin Lin (3)
  Huei-Shyong Wang (3)
  
  1. Division of Paediatric Critical Care, Chang Gung Children Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
  2. Division of Paediatric General Medicine, Chang Gung Children Hospital, Chang Gung University College of Medicine, No.5, Fuxing Street, Guishan Township, Taoyuan, 333, Taiwan
  3. Division of Paediatric Neurology, Chang Gung Children Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
  4. Division of Rheumatology Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  5. Department of Public Health, Biostatistics Consulting Centre, College of Medicine, Chang Gung University, Taoyuan, Taiwan
  6. Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan
  7. Division of Allergy, Asthma and Rheumatology, Department of Paediatrics, Chang Gung Children Hospital, Chang Gung University, Taoyuan, Taiwan
  
• ISSN：1437-160X

文摘

Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital between 1997 and 2008. The survival status and cause of death of the included were ascertained by examining the National Death Registry of Taiwan. Hyperuricaemia was defined as a SUA level greater than 7.0mg/dL. We included 13,241 patients (male, n=7,454; female, n=5,787) of mean age 14.34.9years. During the 82,800 person-years of follow-up, 455 deaths were identified, which corresponded to a crude mortality rate of 5.50 deaths per 1,000 person-years. Compared with individuals with a SUA <6.0mg/dL, those with a SUA of 6.0.9, 9.01.9 and 2mg/dL had an age- and sex-adjusted HR (95% CI) of 1.02 (0.82.26), 1.48 (1.08.02) and 4.73 (2.67.37). After adjustment for age, sex and history of diabetes mellitus and hypertension, hyperuricaemia was found to be associated with a HR (95% CI) of 1.38 (1.13.69; p<0.001) for all-cause mortality. Hyperuricaemia was associated with an increased risk of mortality due to cardiovascular diseases (HR, 5.0; 95% CI 1.793.94; p=0.001) and kidney diseases (11.71; 3.133.78; p<0.001). Paediatric patients with hyperuricaemia were at increased risk of mortality, especially due to kidney and cardiovascular diseases.