Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
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- 作者：Shalini V. Rao ; Guri Solum ; Barbara Niederdorfer ; Kristin G. Nørsett…
- 关键词：Gastrin ; Gastric adenocarcinoma ; Autophagy ; STK11 ; PRKAA2 ; ULK1 signaling cascade ; Cell migration ; Cell survival ; Chemoresistance
- 刊名：BMC Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：5235KB
- 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1471-2407
- 卷排序：17
文摘
BackgroundThe peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a substantial part of the gastric adenocarcinomas express gastrin and CCKBR, the role of gastrin in tumor development is not completely understood. Autophagy has been implicated in mechanisms governing cytoprotection, tumor growth, and contributes to chemoresistance. This study explores the role of autophagy in response to gastrin in gastric adenocarcinoma cell lines.