Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
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- 作者：Huiqiang Wang ; Ke Li ; Linlin Ma ; Shuo Wu ; Jin Hu ; Haiyan Yan…
- 关键词：Enterovirus 71 (EV71) ; Berberine ; Antiviral activity ; Autophagy ; MEK/ERK signaling pathway
- 刊名：Virology Journal
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：2106KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
- 卷排序：14
文摘
BackgroundThe MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR), an isoquinoline alkaloid isolated from Berberis vulgaris L., has been reported to have ability to regulate this signaling pathway and autophagy. Herein, we want to determine whether berberine can inhibit EV71 infection by downregulating the MEK/ERK signaling pathway and autophagy.