Regulation of follicle-stimulating and luteinizing hormone receptor signaling by “regulator of G protein signaling-proteins

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• 作者：C. Castro-Fernández (1)
  G. Maya-Nú?ez (1)
  J. P. Méndez (1)
  
• 关键词：RGS proteins ; FSH receptor ; LH receptor
• 刊名：Endocrine
• 出版年：2004
• 出版时间：October 2004
• 年：2004
• 卷：25
• 期：1
• 页码：49-54
• 全文大小：241KB
• 参考文献：1. Dufau, M. L. (1998). / Annu. Rev. Physiol. 60, 461-96. CrossRef
  2. Hai, M. V., De Roux, N., Ghinea, N., et al. (1999). / Ann. Endocrinol. 60, 89-2.
  3. Gilman, A. G. (1987). / Annu. Rev. Biochem. 56, 615-49. CrossRef
  4. Ulloa-Aguirre, A. and Conn, P. M. (1998). In: / Handbook of physiology. Conn, P. M. (ed.). Oxford University Press: New York.
  5. Druey, K. M., Blumer, K. J., Kang, V. H., and Kehrl, J. H. (1996). / Nature 379, 742-46. CrossRef
  6. Dohlman, H. G. and Thorner, J. (1997). / J. Biol. Chem. 272, 3871-874. CrossRef
  7. De Vries, L., Zheng, B., Fischer, T., Elenko, E., and Farquhar, M. (2000). / Annu. Rev. Pharmacol. Toxicol. 40, 235-71. CrossRef
  8. Chasse, S. A. and Dohlman, H. G. (2003). / Assay Drug Dev. Technol. 1, 357-64. CrossRef
  9. Kehrl, J. H. (1998). / Immunity 8, 1-0. CrossRef
  10. Burchett, S. A. (2000). / J. Neurochem. 75, 1335-351. CrossRef
  11. Kozasa, T. (2001). / Life Sci. 68, 2309-317. CrossRef
  12. Castro-Fernández, C. and Conn P. M. (2002). / Mol. Cell. Endocrinol. 191, 149-56. CrossRef
  13. Xu, X., Zeng, W., Popov, S., et al. (1999). / J. Biol. Chem. 274, 3549-556. CrossRef
  14. Scheschonka, A., Dessauer, C. W., Sinnarajah, S., Chidiac, P., Shi, C. S., and Kehrl, J. H. (2000). / Mol. Pharmacol. 58, 719-28.
  15. Tseng, C.-C. and Zhang, X.-Y. (1998). / Endocrinology 139, 4470-475. CrossRef
  16. Versele, M., De Winde, J. H., and Thevelein, J. M. (1999). / EMBO J. 18, 5577-591. CrossRef
  17. Sinnarajah, S., Dessauer, C. W., Srikumar, D., et al. (2001). / Nature 409, 1051-055. CrossRef
  18. Chatterjee, T. K., Eapen, A. K., and Fisher, R. A. (1997). / J. Biol. Chem. 272, 15481-5487. CrossRef
  19. Shi, C.-S., Lee, S. B., Sinnarajah, S., Dessauer, C. W., Rhee, S. G., and Kehrl, J. H. (2001). / J. Biol. Chem. 276, 24293-4300. CrossRef
  20. Castro-Fernández, C., Janovick, J. A., Brothers, S. P., Fisher, R. A., Ji, T. H., and Conn, P. M. (2002). / Endocrinology 143, 1310-317. CrossRef
  21. Chatterjee, T. K. and Fisher, R. A. (2000). / J. Biol. Chem. 275, 24013-4021. CrossRef
  22. Burchett, S. A. (2003). / J. Neurochem. 87, 551-59. CrossRef
  23. De Vries, L. and Farquhar, M. G. (1999). / Trends Cell. Biol. 9, 138-44. CrossRef
  24. Anger, T., Zhang, W., and Mende, U. (2004). / J. Biol. Chem. 279, 3906-915. CrossRef
  25. Ghavami, A., Hunt, R. A., Olsen, M. A., et al. (2004). / Cell. Signal. 16, 711-21. CrossRef
  26. Lin, X., Janovick, J. A., Brothers, S., Bl?menrohr, M., Bogerd, J., and Conn, P. M. (1998). / Mol. Endocrinol. 12, 161-71. CrossRef
  27. Brothers, S. P., Janovick, J. A., and Conn, P. M. (2003). / J. Clin. Endocrinol. Metab. 88, 6107-2. CrossRef
  28. Huckle, W. R. and Conn, P. M. (1987). / Meth. Enzymol. 141, 149-55. CrossRef
  
• 作者单位：C. Castro-Fernández (1)
  G. Maya-Nú?ez (1)
  J. P. Méndez (1)
  
  1. Research Unit in Developmental Biology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06703, México, D.F., México
  

文摘

Follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) belong to the super-family of G protein-coupled receptors (GPCR); GPCRs are negatively regulated by RGS ("regulators of G protein signaling") proteins. In this study we evaluated the effects of RGS3 and RGS10 on FSHR and LHR ligand binding and effector coupling. FSHR and LHR ligand binding were unchanged in the presence of RGS3 or RGS10. However, signaling by FSHR and LHR was diminished by RGS3 but not by RGS10. This constitutes the first demonstration of an interaction between RGS proteins and LH and FSH signaling pathways and identifies a mechanism for negative regulation of RGS3 on FSHR and LHR signaling.