Different clinical significance of FGFR1–4 expression between diffuse-type and intestinal-type gastric cancer
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- 作者：Mikito Inokuchi ; Hideaki Murase ; Sho Otsuki…
- 关键词：Fibroblast growth factor receptor 1 ; Fibroblast growth factor receptor 2 ; Fibroblast growth factor receptor 3 ; Fibroblast growth factor receptor 4 ; Gastric cancer ; Immunohistochemistry
- 刊名：World Journal of Surgical Oncology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：1206KB
- 刊物主题：Surgical Oncology;
- 出版者：BioMed Central
- ISSN：1477-7819
- 卷排序：15
文摘
BackgroundReceptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1, 2, 3, and 4 in gastric cancer. The aim of the present study was to reevaluate the clinical significance of FGFR1–4 expression separately in DGC and IGC.