Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease

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• 作者：Micaela Brandolini ; Marta Corbella ; Annalisa De Silvestri ; Carmine Tinelli…
• 关键词：Bloodstream infection ; Liver cirrhosis ; Chronic hepatitis
• 刊名：Infection
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：43
• 期：5
• 页码：561-567
• 全文大小：426 KB
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• 作者单位：Micaela Brandolini (1)
  Marta Corbella (1) (2)
  Annalisa De Silvestri (2)
  Carmine Tinelli (1)
  Giulia Albonico (3)
  Riccardo Albertini (3)
  Serena Ludovisi (4)
  Raffaele Bruno (5)
  Piero Marone (1)
  Lorenzo Minoli (4)
  Elena Seminari (4)
  
  1. SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  2. Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  3. Laboratorio Analisi Chimico-Cliniche, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  4. Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  5. Divisione Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Infectious Diseases
  General Practice and Family Medicine
  Internal Medicine
  
• 出版者：Urban & Vogel
• ISSN：1439-0973

文摘

Observational retrospective study to evaluate the etiology, the outcome and the risk factors of bloodstream infections (BSIs) in patients with liver disease. One hundred and forty-eight BSIs were diagnosed (infection rate: 0.60 per 100 days of hospital stay), 62 BSIs (41.9 %) were associated with Gram-positive bacteria (infection rate: 0.25 per 100 days of hospital stay) and 80 (54.4 %) with Gram-negative bacteria (infection rate: 0.32 per 100 days of hospital stay). Admission-associated mortality was higher in patients with BSI than in those without BSI (20.6 versus 5.0 %, p < 0.001). Patients with cirrhosis had an increased risk to develop a BSI compared with patients with chronic hepatitis, specifically for Gram-positive (and Staphylococcus spp)-related BSI. Keywords Bloodstream infection Liver cirrhosis Chronic hepatitis