Stem cells and microenvironment: Integration of biochemical and mechanical factors

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• 作者：D. S. Kostyushev (1) (6)
  V. N. Simirskii (2)
  S. Song (3)
  M. A. Paltsev (4) (5) (6)
  D. A. Gnatenko (1) (6)
  S. V. Suchkov (1) (6) (7)
  
• 关键词：stem cell ; microenvironment ; mechanosensors ; mechanotransduction ; integrins
• 刊名：Biology Bulletin Reviews
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：4
• 期：4
• 页码：263-275
• 全文大小：903 KB
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• 作者单位：D. S. Kostyushev (1) (6)
  V. N. Simirskii (2)
  S. Song (3)
  M. A. Paltsev (4) (5) (6)
  D. A. Gnatenko (1) (6)
  S. V. Suchkov (1) (6) (7)
  
  1. Sechenov First Moscow State Medical University, ul. Trubetskaya 8/2, Moscow, 119991, Russia
  6. European Association for Predictive, Preventive and Personalised Medicine (EPMA), Avenue des Volontaires 19, Brussels, 1160, Belgium
  2. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia
  3. Department of Pharmaceutics, University of Florida College of Pharmacy Powell Gene Therapy Center, Genetics Institute 1600 SW Archer Rd, JHMHC, Gainesville, USA
  4. National Research Center 鈥淜urchatov Institute,鈥? pl. Akademika Kurchatova 1, Moscow, 123098, Russia
  5. Institute of Translational Medicine, People鈥檚 Friendship University of Russia, Moscow, Russia
  7. Evdokimov Moscow State Medical Stomatological University, ul. Delegatskaya 20/1, Moscow, 127473, Russia
  
• ISSN：2079-0872

文摘

The role of the microenvironment in the regulation of the main stem cell functions is considered. Special attention is paid to the effects of mechanical interactions and mechanical properties of the substrate on self-renewal, maintenance of potency, and differentiation in stem cells in vivo and in vitro. Primary cilia, mechanosensitive channels, receptors coupled with G proteins, and the proteins of intercellular junctions can be mechanosensors. In turn, the major role in mechanotransduction belongs to integrins, a large family of extracellular matrix receptors. Integrins are part of focal adhesions. They form bridges to link the cell membrane to the cytoskeleton and nucleus. The study of the integration of the biochemical and mechanical factors of the microenvironment is essential for the introduction of stem cell technology into regenerative medicine.