Regeneration and fibrosis of corneal tissues
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- 作者：V. N. Simirskii (1)
- 关键词：tissue regeneration ; fibrosis ; epithelial ; mesenchymal transition ; myofibroblasts ; stem cell ; cell and gene therapy ; cornea
- 刊名：Russian Journal of Developmental Biology
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：45
- 期：5
- 页码：257-266
- 全文大小：1,063 KB
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1. Kol鈥檛sov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia - ISSN：1608-3326
文摘
In this review, the features of the regeneration of corneal tissue and its disorders leading to the development of fibrosis are considered. The data on the presence of stem (clonogenic) cell pool in the corneal tissues (epithelium, endothelium, stroma) are given; these cells can serve as a source for regeneration of the tissues at injury or various diseases. The main steps of regeneration of corneal tissues and their disorders that lead to outstripping proliferation of myofibroblasts and secretion of extracellular matrix in the wound area and eventually cause the formation of connective tissue scar and corneal opacity are considered. Particular attention is given to the successes of translational medicine in the treatment of corneal tissue fibrosis. The methods of cell therapy aimed at the restoration of stem cell pool of corneal tissues are the most promising. Gene therapy provides more opportunities; one of its main objectives is the suppression of the myofibroblast proliferation responsible for the development of fibrosis.