Effect of single doses of IV palonosetron, up to 2.25 mg, on the QTc interval duration: a double-blind, randomized, parallel group study in healthy volunteers

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• 作者：Joel Morganroth ; Kristen K. Flaharty ; Simona Parisi…
• 关键词：Palonosetron ; QTc interval ; 5 ; HT3 receptor antagonists ; Chemotherapy ; induced nausea and vomiting
• 刊名：Supportive Care in Cancer
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：24
• 期：2
• 页码：621-627
• 全文大小：435 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Nursing
  Nursing Management and Research
  Pain Medicine
  Rehabilitation Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-7339

文摘

Purpose The use of serotonin type 3 (5-HT₃) receptor antagonists (RAs) in the prevention of nausea and vomiting caused by emetogenic chemotherapy is part of a comprehensive management strategy for patients undergoing chemotherapy. Electrocardiographic effects have been reported in patients after intravenous administration of 5-HT₃ RAs. The present study investigated the electrocardiogram (ECG) profile of the 5-HT₃ RA palonosetron following International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) E14 Guidelines.