Osteoporotic Fracture Models

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• 作者：A. Hamish Simpson (1)
  Iain R. Murray (1)
  
• 关键词：Osteoporosis ; Fracture healing ; Animal model
• 刊名：Current Osteoporosis Reports
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：13
• 期：1
• 页码：9-15
• 全文大小：260 KB
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• 作者单位：A. Hamish Simpson (1)
  Iain R. Murray (1)
  
  1. Department of Trauma and Orthopaedics, The University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
  
• 刊物主题：Orthopedics; Epidemiology;
• 出版者：Springer US
• ISSN：1544-2241

文摘

Animal models are widely used to investigate the pathogenesis of osteoporosis and for the clinical testing of anti-resorptive drugs. However, osteoporotic fracture models designed to investigate novel ways to treat fractures of osteoporotic bone must fulfil requirements distinct from those of pharmacological testing. Bone strength and toughness, implant fixation and osteointegration and fracture repair are of particular interest. Osteoporotic models should reflect the underlying clinical scenario be that primary type 1 (post-menopausal) osteoporosis, primary type 2 (senile) osteoporosis or secondary osteoporosis. In each scenario, small and large animal models have been developed. While rodent models facilitate the study of fractures in strains specifically established to facilitate understanding of the pathologic basis of disease, concerns remain about the relevance of small animal fracture models to the human situation. There is currently no all-encompassing model, and the choice of species and model must be individualized to the scientific question being addressed.