Simulation of the fibroblast effect on electrical activity of sinoatrial node cells

详细信息    查看全文

• 作者：A. S. Tolstokorov ; R. A. Syunyaev ; R. R. Aliev
• 关键词：computer simulation ; sinoatrial node ; gap junctions ; fibroblasts
• 刊名：Biophysics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：60
• 期：2
• 页码：256-262
• 全文大小：454 KB
• 参考文献：1.H. Dobrzynski, J. Li, J. Tellez, et al., Circulation 111, 846 (2005).View Article
  2.T. Opthof, B. de Jonge, H. J. Jongsma, and L. N. Bouman, Eur. Heart J. 8, 1249 (1987).
  3.A. Biernacka and N. G. Frangogiannis, Aging and Disease 2 (2), 158 (2011).
  4.P. Camelliti, C. R. Green, I. LeGrice, and P. Kohl, Circ. Res. 94 (6), 828 (2004).View Article
  5.Y. Shibukawa, E. L. Chilton, K. A. MacCannell, et al., Biophys. J. 88 (6), 3924 (2005).View Article
  6.L. Chilton, S. Ohya, D. Freed, et al., Am. J. Physiol. Heart Circ. Physiol. 288 (6), H2931 (2005).View Article
  7.H. Zhang, A. V. Holden, I. Kodama, et al., Am. J. Physiol. 279, H397(2000).
  8.R. R. Aliev, V. V. Fedorov, and L. V. Rozenshtraukh, Dokl. Ross. Akad. Nauk 397 (5), 697 (2004).
  9.R. R. Aliev, V. V. Fedorov, and L. V. Rozenshtraukh, Dokl. Biochem. Biophys. 402 (4), 223 (2005).View Article
  10.R. R. Aliev and L. M. Chailakhyan, Dokl. Biochem. Biophys. 402 (5), 236 (2005)View Article
  11.R. R. Aliev, Conceptual and Detailed Models of Myocardium Electrical Activity (Lambert Acad. Publ., 2012). ISBN 978-3-8465-3943-9.
  12.K. A. MacCannell, H. Bazzazi, L. Chilton, et al., Biophys. J. 92 (11), 4121 (2007).View Article
  13.H. Honjo, M. R. Boyett, I. Kodama, and J. Toyama, J. Physiol. 496 (Pt 3), 795 (1996)View Article
  14.A. Kamkin, I. Kiseleva, G. Isenberg, et al., Prog. Biophys. Mol. Biol. 82 (1鈥?), 111 (2003).View Article
  15.R. A. Syunyaev and R. R. Aliev, Biophysics (Moscow) 57 (5), 676 (2012).MathSciNet View Article
  
• 作者单位：A. S. Tolstokorov (1) (2)
  R. A. Syunyaev (1) (2) (3)
  R. R. Aliev (1) (2) (3)
  
  1. Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow oblast, 141700, Russia
  2. Research Institute of Cardiology, Federal Research and Clinical Center, Federal Medical-Biological Agency of Russia, Moscow, 115682, Russia
  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia
  
• 刊物主题：Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1555-6654

文摘

It was found via the mathematical simulation of the effect of fibroblasts on the electrical activity of the sinoatrial node cells that the interaction with fibroblasts through gap junctions increases the oscillation frequency of pacemakers. Under the effect of fibroblasts, the oscillation amplitude of a true pacemaker decreases until the end of the spontaneous activity. The oscillation amplitude of a latent pacemaker decreases considerably less.