“HLA-G 3′UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population”

详细信息    查看全文

• 作者：Maheshkumar Poomarimuthu ; Sivakumar Elango…
• 关键词：Human leukocyte antigen G ; Rheumatic fever ; Rheumatic heart disease ; Polymorphism ; Autoimmunity
• 刊名：Pediatric Rheumatology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：333KB
• 刊物主题：Pediatrics; Rheumatology;
• 出版者：BioMed Central
• ISSN：1546-0096
• 卷排序：15

文摘

BackgroundRheumatic heart disease (RHD) is an autoimmune disease where cross reactive CD4+ T cells are involved in the pathogenesis of valvular damage. Human Leukocyte Antigen-G (HLA-G), an immunosuppressive molecule playing a crucial role in the inhibition of T cell response is associated with the pathogenesis of various autoimmune and inflammatory diseases. Genetic polymorphisms within the 3′untranslated region (UTR) of HLA-G influences its expression and thus disease pathogenesis. Hence, the present study aims to unravel the association of 14 bp Ins/Del (rs66554220) and +3142 C/G (rs1063320) polymorphisms in 3′ UTR of HLA-G with RHD.