Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

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• 作者：Kanjoormana A. Manu (1)
  Muthu K. Shanmugam (1)
  Feng Li (1)
  Luxi Chen (1) (2)
  Kodappully Sivaraman Siveen (1)
  Kwang Seok Ahn (3)
  Alan Prem Kumar (1) (2) (4) (5)
  Gautam Sethi (1) (2)
  
• 关键词：Gastric cancer ; Chemoresistance ; Simvastatin ; Apoptosis ; NF ; 魏B
• 刊名：Journal of Molecular Medicine
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：92
• 期：3
• 页码：267-276
• 全文大小：740 KB
• 参考文献：1. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60:277鈥?00 CrossRef
  2. Zhao AG, Li T, You SF, Zhao HL, Gu Y, Tang LD, Yang JK (2008) Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice. World J Gastroenterol 14:693鈥?00 CrossRef
  3. Kim HK, Choi IJ, Kim CG, Kim HS, Oshima A, Michalowski A, Green JE (2011) A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PLoS One 6:e16694 CrossRef
  4. Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G (2012) First evidence that gamma-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-kappaB pathway. Clin Cancer Res 18:2220鈥?229 CrossRef
  5. Li F, Sethi G (2010) Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805:167鈥?80
  6. Sethi G, Tergaonkar V (2009) Potential pharmacological control of the NF-魏B pathway. Trends Pharmacol Sci 30:313鈥?21 CrossRef
  7. Long YM, Ye S, Rong J, Xie WR (2008) Nuclear factor kappa B: a marker of chemotherapy for human stage IV gastric carcinoma. World J Gastroenterol 14:4739鈥?744 CrossRef
  8. Yang YJ, Chuang CC, Yang HB, Lu CC, Sheu BS (2012) Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFkappaB pathways. BMC Microbiol 12:38 CrossRef
  9. Thompson JS, Sood A, Arora R (2010) Statins and cancer: a potential link? Am J Ther 17:e100鈥揺104
  10. Lee J, Lee I, Han B, Park JO, Jang J, Park C, Kang WK (2011) Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. J Natl Cancer Inst 103:674鈥?88 CrossRef
  11. Kah J, Wustenberg A, Keller AD, Sirma H, Montalbano R, Ocker M, Volz T, Dandri M, Tiegs G, Sass G (2012) Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep 28:1077鈥?083
  12. Park YH, Seo SY, Lee E, Ku JH, Kim HH, Kwak C (2012) Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating NF-kB pathway. J Urol. 189: 1547鈥?552
  13. Gopalan A, Yu W, Sanders BG, Kline K (2013) Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Lett 328:285鈥?96 CrossRef
  14. Oh B, Kim TY, Min HJ, Kim M, Kang MS, Huh JY, Kim Y, Lee DS (2013) Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells. Anticancer Drugs 24:20鈥?1 CrossRef
  15. Gopalan A, Yu W, Sanders BG, Kline K (2012) Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. Cancer Lett. 329: 9鈥?6
  16. Pelaia G, Gallelli L, Renda T, Fratto D, Falcone D, Caraglia M, Busceti MT, Terracciano R, Vatrella A, Maselli R et al (2012) Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells. Cell Prolif 45:557鈥?65 CrossRef
  17. Kochuparambil ST, Al-Husein B, Goc A, Soliman S, Somanath PR (2011) Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. J Pharmacol Exp Ther 336:496鈥?05 CrossRef
  18. Ahn KS, Sethi G, Aggarwal BB (2007) Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol 178:2507鈥?516
  19. Ahn KS, Sethi G, Aggarwal BB (2008) Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. Biochem Pharmacol 75:907鈥?13 CrossRef
  20. Ahn KS, Sethi G, Chaturvedi MM, Aggarwal BB (2008) Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway. Int J Cancer 123:1733鈥?740 CrossRef
  21. Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY (2011) Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. Eur J Pharmacol 670:356鈥?64 CrossRef
  22. Kidera Y, Tsubaki M, Yamazoe Y, Shoji K, Nakamura H, Ogaki M, Satou T, Itoh T, Isozaki M, Kaneko J et al (2010) Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. J Exp Clin Cancer Res 29:127 CrossRef
  23. Relja B, Meder F, Wang M, Blaheta R, Henrich D, Marzi I, Lehnert M (2011) Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. Int J Oncol 38:879鈥?85 CrossRef
  24. Miller T, Yang F, Wise CE, Meng F, Priester S, Munshi MK, Guerrier M, Dostal DE, Glaser SS (2011) Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity. Dig Liver Dis 43:395鈥?03 CrossRef
  25. Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT et al (2012) Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor gamma activation pathway in gastric cancer. J Biol Chem 287:38028鈥?8040 CrossRef
  26. Camp ER, Li J, Minnich DJ, Brank A, Moldawer LL, MacKay SL, Hochwald SN (2004) Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg 199:249鈥?58 CrossRef
  27. Yu LL, Dai N, Yu HG, Sun LM, Si JM (2010) Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. Oncol Rep 24:113鈥?19
  28. Nam SY, Ko YS, Jung J, Yoon J, Kim YH, Choi YJ, Park JW, Chang MS, Kim WH, Lee BL (2011) A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-kappaB promotes gastric tumour growth and angiogenesis. Br J Cancer 104:166鈥?74 CrossRef
  29. Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR et al (2011) Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 鈥榮temness鈥?via the bone morphogenetic protein pathway. Gut 60:1544鈥?553 CrossRef
  30. Sadaria MR, Reppert AE, Yu JA, Meng X, Fullerton DA, Reece TB, Weyant MJ (2011) Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells. J Thorac Cardiovasc Surg 142:1152鈥?160 CrossRef
  31. Relja B, Meder F, Wilhelm K, Henrich D, Marzi I, Lehnert M (2010) Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med 26:735鈥?41 CrossRef
  32. Han JY, Lee SH, Yoo NJ, Hyung LS, Moon YJ, Yun T, Kim HT, Lee JS (2011) A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer. Clin Cancer Res 17:1553鈥?560 CrossRef
  33. Sadeghi-Aliabadi H, Minaiyan M, Dabestan A (2010) Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells. Res Pharm Sci 5:127鈥?33
  34. Xiao H, Yang CS (2008) Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. Int J Cancer 123:983鈥?90 CrossRef
  35. Leung HW, Chan AL, Lo D, Leung JH, Chen HL (2012) Common cancer risk and statins: a population-based case鈥揷ontrol study in a Chinese population. Expert Opin Drug Saf. 12:19鈭?7
  
• 作者单位：Kanjoormana A. Manu (1)
  Muthu K. Shanmugam (1)
  Feng Li (1)
  Luxi Chen (1) (2)
  Kodappully Sivaraman Siveen (1)
  Kwang Seok Ahn (3)
  Alan Prem Kumar (1) (2) (4) (5)
  Gautam Sethi (1) (2)
  
  1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
  2. Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore, 117599, Singapore
  3. College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea
  4. School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Western Australia, 6009, Australia
  5. Department of Biological Sciences, University of North Texas, Denton, TX, 76203, USA
  
• ISSN：1432-1440

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