Semi-automated radiosynthesis of 18F-labeled l-arginine derivative as a potential PET tracer for lung cancer imaging

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• 作者：Siyuan Gao ; Ganghua Tang ; Shuguang Zhu…
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：309
• 期：3
• 页码：1257-1264
• 全文大小：1,067 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780
• 卷排序：309

文摘

In this work, we designed and synthesized N-(2-[18F]-flouroptopionyl)-l-arginine ([18F]FPARG), which was an analogue of l-arginine for tumor positron emission tomography (PET) imaging. Semi-automated radiosynthesis of [18F]FPARG was performed from the reaction of l-arginine with 4-nitropheyl-2-[18F]flouropropionate ([18F]NFP) by multi-step procedure on the modified PET-MF-2V-IT-1 synthesizer. The uncorrected radiochemical yield of [18F]FPARG was 15 ± 3 % (n = 10) with more than 98 % radiochemical purity. The small-animal PET/CT fused imaging showed that liver and urinary bladder were the primary excretion route of this tracer.Keywordsl-Arginine derivative18FPET imagingLung cancer