Accelerated Regeneration of Skin Injury by Co-transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles

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• 作者：Shengjun Shi ; Siyuan Jia ; Jingwen Liu ; Guangping Chen
• 关键词：hUC ; Wharton’s jelly ; MSCs ; Skin microparticles ; Skin wound ; Tissue engineering
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：71
• 期：2
• 页码：951-956
• 全文大小：802 KB
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• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

This study was set to explore a new strategy for repairing skin wounds, co-transplantation of mesenchymal stem cells from Wharton’s Jelly of the human umbilical cord (hUC-Wharton’s jelly-MSCs) and microparticles. A mixture of hUC-Wharton’s jelly-MSCs and microparticles was co-transplanted to 10-mm diameter, full-thickness, mid-dorsal, excisional skin wounds of mice. After 7, 14, and 21?days, the tissue sections were sampled for reconstruction analysis and histological examination. Our results showed that hUC-Wharton’s jelly-MSCs possess the potentials for multi-directional differentiation. After co-transplantation, there was remarkable development of newborn skin and its appendages. Newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands were observed. This promising innovative strategy could significantly increase the quality of repair and regeneration of skin after injuries.