The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition

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• 作者：Akihiro Tojo ; Kensuke Asaba ; Satoshi Kinugasa…
• 关键词：Fanconi syndrome ; κ light chain ; Myeloma ; Proximal tubule ; SGLT2 ; NaPi ; IIa ; URAT1
• 刊名：Medical Molecular Morphology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：49
• 期：1
• 页码：48-52
• 全文大小：1,463 KB
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• 作者单位：Akihiro Tojo (1)
  Kensuke Asaba (1)
  Satoshi Kinugasa (1)
  Yoichiro Ikeda (1)
  Yukako Shintani (2)
  Masashi Fukayama (2)
  Masaomi Nangaku (1)
  
  1. Division of Nephrology and Endocrinology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
  2. Department of Pathology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Pathology
  Biological Microscopy
  Molecular Medicine
  
• 出版者：Springer Japan
• ISSN：1860-1499

文摘

In a case of acquired Fanconi syndrome associated with smoldering myeloma, we confirmed the deposition of protease-resistant κ light chain proteins in a proximal tubular injury and found the decreased expression of apical tubular transporters including sodium glucose co-transporter, sodium phosphate co-transporter, uric acid transporter 1, and a decrease of Na+/K+-ATPase in the basolateral membrane. The protease-resistant kappa light chain has a pathological role in the expression of tubular transporters in the proximal tubule and causes Fanconi syndrome associated with smoldering myeloma.