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rop="datePublished">May 2014 , range">14:O15 , Open Access This content is freely available online to anyone, anywhere at any time.
rop="headline">Carcinovic cohort: prognostic factors of death in HIV/HCV coinfected patients with hepatocellular carcinoma (HCC)
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rs"> - r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22M+Gelu-Simeon%22" itemprop="name">M Gelu-Simeon, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22M+Lewin%22" itemprop="name">M Lewin, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22R+Sobesky%22" itemprop="name">R Sobesky, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22M+Ostos%22" itemprop="name">M Ostos, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22T+Bayan%22" itemprop="name">T Bayan, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22F+Boufassa%22" itemprop="name">F Boufassa, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22L+Meyer%22" itemprop="name">L Meyer, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22A+Persoz%22" itemprop="name">A Persoz, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22E+Teicher%22" itemprop="name">E Teicher, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22H+Fontaine%22" itemprop="name">H Fontaine, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22D+Salmon-C%C3%A9ron%22" itemprop="name">D Salmon-Céron, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22O+Seror%22" itemprop="name">O Seror, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22J-C+Trinchet%22" itemprop="name">J-C Trinchet, r>
- r" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person"> ref="/search?facet-author=%22J-C+Duclos-Vall%C3%A9e%22" itemprop="name">J-C Duclos-Vallée r>
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Background and aim
We have previously reported a more advanced radiological presentation in HIV+/HCV+ than HIV-/HCV+ patients (pts). The aim of our study was to define prognostic factors of death in HIV+/HCV+ pts with HCC.
Methods
Cases of HCC in HIV+/HCV+ pts were obtained from the 3 ANRS Prethevic, HepaVih and CirVir cohorts. Imaging was reviewed according to EASL criteria.
Results
Fifty HIV+/HCV+ coinfected pts (n=44 men (88%), median age 50 years [40-74], median CD4 cell count 334/mm3 [58-1621], n=28 Child A cirrhosis (60%)) developed HCC. Thirty-one (63%) pts presented cirrhosis decompensation before HCC diagnosis. At HCC diagnosis, median serum aFP was 20.4 [1.9-198,900] ng/ml, 38 (76%) pts had a nodular tumor (median main diameter 23.5 [11-70] cm) and 12 (24%) pts an infiltrating form (62.5 [10-130] cm), p=0.007. Tumor portal thrombosis was diagnosed in 14 (28%) pts. A curative or a palliative procedure was further performed in 22 (44%) pts and 20 (40%) pts, respectively. The 2-years